Human Gene RCOR2 (ENST00000301459.5) from GENCODE V44
Description: Homo sapiens REST corepressor 2 (RCOR2), transcript variant 1, mRNA. (from RefSeq NM_173587)
Gencode Transcript: ENST00000301459.5
Gencode Gene: ENSG00000167771.6
Transcript (Including UTRs)
Position: hg38 chr11:63,911,230-63,917,164 Size: 5,935 Total Exon Count: 12 Strand: -
Coding Region
Position: hg38 chr11:63,911,865-63,916,456 Size: 4,592 Coding Exon Count: 12
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: RCOR2_HUMAN
DESCRIPTION: RecName: Full=REST corepressor 2;
FUNCTION: May act as a component of a corepressor complex that represses transcription (Potential).SUBCELLULAR LOCATION: Nucleus (By similarity).SIMILARITY: Belongs to the CoREST family.SIMILARITY: Contains 1 ELM2 domain.SIMILARITY: Contains 2 SANT domains.SEQUENCE CAUTION: Sequence=AAH10608.1; Type=Miscellaneous discrepancy; Note=Chimera;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR000949 - ELM2_dom
IPR009057 - Homeodomain-like
IPR001005 - SANT/Myb
IPR017884 - SANT_dom
Pfam Domains: PF01448 - ELM2 domain
PF00249 - Myb-like DNA-binding domain
ModBase Predicted Comparative 3D Structure on Q8IZ40
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019899 enzyme binding
GO:0044212 transcription regulatory region DNA binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component: GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0017053 transcriptional repressor complex
Descriptions from all associated GenBank mRNAs
BC023587 - Homo sapiens REST corepressor 2, mRNA (cDNA clone MGC:23462 IMAGE:4762190), complete cds.BC010608 - Homo sapiens REST corepressor 2, mRNA (cDNA clone IMAGE:4157757), partial cds.AB593132 - Homo sapiens RCOR2 mRNA for REST corepressor 2, complete cds, clone: HP08658-RBd91D02.JD456608 - Sequence 437632 from Patent EP1572962.JD465725 - Sequence 446749 from Patent EP1572962.JD195229 - Sequence 176253 from Patent EP1572962.JD426431 - Sequence 407455 from Patent EP1572962.JD525007 - Sequence 506031 from Patent EP1572962.JD243439 - Sequence 224463 from Patent EP1572962.JD060343 - Sequence 41367 from Patent EP1572962.JD395807 - Sequence 376831 from Patent EP1572962.JD255501 - Sequence 236525 from Patent EP1572962.JD233596 - Sequence 214620 from Patent EP1572962.JD545285 - Sequence 526309 from Patent EP1572962.JD404055 - Sequence 385079 from Patent EP1572962.JD457904 - Sequence 438928 from Patent EP1572962.JD116633 - Sequence 97657 from Patent EP1572962.KJ900545 - Synthetic construct Homo sapiens clone ccsbBroadEn_09939 RCOR2 gene, encodes complete protein.JD420434 - Sequence 401458 from Patent EP1572962.JD189613 - Sequence 170637 from Patent EP1572962.JD470584 - Sequence 451608 from Patent EP1572962.JD205011 - Sequence 186035 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: ENST00000301459.1, ENST00000301459.2, ENST00000301459.3, ENST00000301459.4, NM_173587, Q8IZ40, Q96FP3, RCOR2_HUMAN, uc001nyc.1, uc001nyc.2, uc001nyc.3, uc001nyc.4UCSC ID: ENST00000301459.5RefSeq Accession: NM_173587
Protein: Q8IZ40
(aka RCOR2_HUMAN)
CCDS: CCDS8052.1
Methods, Credits, and Use Restrictions
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