Human Gene TAS2R7 (ENST00000240687.2) from GENCODE V44
Description: Homo sapiens taste 2 receptor member 7 (TAS2R7), mRNA. (from RefSeq NM_023919) RefSeq Summary (NM_023919): This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000240687.2 Gencode Gene: ENSG00000121377.2 Transcript (Including UTRs) Position: hg38 chr12:10,801,532-10,802,627 Size: 1,096 Total Exon Count: 1 Strand: - Coding Region Position: hg38 chr12:10,801,614-10,802,570 Size: 957 Coding Exon Count: 1
ID:TA2R7_HUMAN DESCRIPTION: RecName: Full=Taste receptor type 2 member 7; Short=T2R7; AltName: Full=Taste receptor family B member 4; Short=TRB4; FUNCTION: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells. MISCELLANEOUS: Several bitter taste receptors are expressed in a single taste receptor cell. SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05296 - Taste receptor protein (TAS2R)
ModBase Predicted Comparative 3D Structure on Q9NYW3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0050896 response to stimulus GO:0050909 sensory perception of taste
US Server
