Human Gene ART4 (ENST00000228936.6) from GENCODE V44
Description: Homo sapiens ADP-ribosyltransferase 4 (inactive) (Dombrock blood group) (ART4), transcript variant 1, mRNA. (from RefSeq NM_021071) RefSeq Summary (NM_021071): This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000228936.6 Gencode Gene: ENSG00000111339.12 Transcript (Including UTRs) Position: hg38 chr12:14,825,569-14,843,526 Size: 17,958 Total Exon Count: 3 Strand: - Coding Region Position: hg38 chr12:14,829,371-14,843,113 Size: 13,743 Coding Exon Count: 3
ID:NAR4_HUMAN DESCRIPTION: RecName: Full=Ecto-ADP-ribosyltransferase 4; EC=2.4.2.31; AltName: Full=ADP-ribosyltransferase C2 and C3 toxin-like 4; Short=ARTC4; AltName: Full=Dombrock blood group carrier molecule; AltName: Full=Mono(ADP-ribosyl)transferase 4; AltName: Full=NAD(P)(+)--arginine ADP-ribosyltransferase 4; AltName: CD_antigen=CD297; Flags: Precursor; CATALYTIC ACTIVITY: NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine. CATALYTIC ACTIVITY: NADP(+) + protein-L-arginine = nicotinamide + N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. TISSUE SPECIFICITY: Expressed in spleen and T-cells. POLYMORPHISM: DO is responsible for the Dombrock blood group system. The molecular basis of the Do(a)/Do(b) blood group antigen is a single variation in position 265; Asn-265 corresponds to Do(a) and Asp-265 to Do(b). It is also responsible for the antigens Gregory [Gy(a)], Holley [Hy] and Joseph [Jo(a)]. SIMILARITY: Belongs to the Arg-specific ADP-ribosyltransferase family. WEB RESOURCE: Name=dbRBC/BGMUT; Note=Blood group antigen gene mutation database; URL="http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=dombrock"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/do/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q93070
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
