Human Gene KRT76 (ENST00000332411.2) from GENCODE V44
Description: Homo sapiens keratin 76 (KRT76), mRNA. (from RefSeq NM_015848) RefSeq Summary (NM_015848): Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jun 2009]. Gencode Transcript: ENST00000332411.2 Gencode Gene: ENSG00000185069.2 Transcript (Including UTRs) Position: hg38 chr12:52,768,155-52,777,345 Size: 9,191 Total Exon Count: 9 Strand: - Coding Region Position: hg38 chr12:52,768,713-52,777,291 Size: 8,579 Coding Exon Count: 9
ID:K22O_HUMAN DESCRIPTION: RecName: Full=Keratin, type II cytoskeletal 2 oral; AltName: Full=Cytokeratin-2P; Short=CK-2P; Short=K2P; AltName: Full=Keratin-76; Short=K76; AltName: Full=Type-II keratin Kb9; FUNCTION: Probably contributes to terminal cornification. SUBUNIT: Heterotetramer of two type I and two type II keratins. DEVELOPMENTAL STAGE: Synthesized during maturation of epidermal keratinocytes. MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). SIMILARITY: Belongs to the intermediate filament family. SEQUENCE CAUTION: Sequence=BAG61375.1; Type=Erroneous termination; Positions=267; Note=Translated as Glu; WEB RESOURCE: Name=Human Intermediate Filament Mutation Database; URL="http://www.interfil.org";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00038 - Intermediate filament protein
ModBase Predicted Comparative 3D Structure on Q01546
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.