Human Gene KRT76 (ENST00000332411.2) from GENCODE V44
  Description: Homo sapiens keratin 76 (KRT76), mRNA. (from RefSeq NM_015848)
RefSeq Summary (NM_015848): Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jun 2009].
Gencode Transcript: ENST00000332411.2
Gencode Gene: ENSG00000185069.2
Transcript (Including UTRs)
   Position: hg38 chr12:52,768,155-52,777,345 Size: 9,191 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg38 chr12:52,768,713-52,777,291 Size: 8,579 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:52,768,155-52,777,345)mRNA (may differ from genome)Protein (638 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: K22O_HUMAN
DESCRIPTION: RecName: Full=Keratin, type II cytoskeletal 2 oral; AltName: Full=Cytokeratin-2P; Short=CK-2P; Short=K2P; AltName: Full=Keratin-76; Short=K76; AltName: Full=Type-II keratin Kb9;
FUNCTION: Probably contributes to terminal cornification.
SUBUNIT: Heterotetramer of two type I and two type II keratins.
DEVELOPMENTAL STAGE: Synthesized during maturation of epidermal keratinocytes.
MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
SIMILARITY: Belongs to the intermediate filament family.
SEQUENCE CAUTION: Sequence=BAG61375.1; Type=Erroneous termination; Positions=267; Note=Translated as Glu;
WEB RESOURCE: Name=Human Intermediate Filament Mutation Database; URL="http://www.interfil.org";

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.02 RPKM in Testis
Total median expression: 0.05 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -11.7054-0.217 Picture PostScript Text
3' UTR -172.00558-0.308 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016044 - F
IPR001664 - IF
IPR018039 - Intermediate_filament_CS
IPR003054 - Keratin_II

Pfam Domains:
PF00038 - Intermediate filament protein

ModBase Predicted Comparative 3D Structure on Q01546
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005198 structural molecule activity

Biological Process:
GO:0007010 cytoskeleton organization
GO:0008544 epidermis development
GO:0031424 keratinization
GO:0043473 pigmentation
GO:0048733 sebaceous gland development
GO:0070268 cornification

Cellular Component:
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005882 intermediate filament
GO:0045095 keratin filament
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  M99063 - Homo sapiens cytokeratin 2 mRNA, complete cds.
JD160445 - Sequence 141469 from Patent EP1572962.
JD126356 - Sequence 107380 from Patent EP1572962.
JD377024 - Sequence 358048 from Patent EP1572962.
JD456185 - Sequence 437209 from Patent EP1572962.
AK299390 - Homo sapiens cDNA FLJ60838 complete cds, highly similar to Keratin, type II cytoskeletal 2 oral.
JD184422 - Sequence 165446 from Patent EP1572962.
JD176590 - Sequence 157614 from Patent EP1572962.
JD425172 - Sequence 406196 from Patent EP1572962.
JD565387 - Sequence 546411 from Patent EP1572962.
JD270846 - Sequence 251870 from Patent EP1572962.
JD053941 - Sequence 34965 from Patent EP1572962.
JD503561 - Sequence 484585 from Patent EP1572962.
JD417953 - Sequence 398977 from Patent EP1572962.
BC167839 - Synthetic construct Homo sapiens clone IMAGE:100068229, MGC:195846 keratin 76 (KRT76) mRNA, encodes complete protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q01546 (Reactome details) participates in the following event(s):

R-HSA-6805546 Keratin type I binds keratin type II
R-HSA-6805573 Keratin type I/type II heterodimers form tetramers
R-HSA-6806613 Keratin tetramers bind to form unit length filaments
R-HSA-6805567 Keratinization
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: B4DRR3, ENST00000332411.1, K22O_HUMAN, KRT2B, KRT2P, NM_015848, Q01546, Q7Z795, uc001sax.1, uc001sax.2, uc001sax.3
UCSC ID: ENST00000332411.2
RefSeq Accession: NM_015848
Protein: Q01546 (aka K22O_HUMAN)
CCDS: CCDS8838.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.