ID:OASL_HUMAN DESCRIPTION: RecName: Full=2'-5'-oligoadenylate synthase-like protein; AltName: Full=2'-5'-OAS-related protein; Short=2'-5'-OAS-RP; AltName: Full=59 kDa 2'-5'-oligoadenylate synthase-like protein; AltName: Full=Thyroid receptor-interacting protein 14; Short=TR-interacting protein 14; Short=TRIP-14; AltName: Full=p59 OASL; Short=p59OASL; FUNCTION: Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. SUBUNIT: Specifically interacts with the ligand binding domain of the thyroid receptor (TR). TRIP14 does not require the presence of thyroid hormone for its interaction. Binds MBD1. SUBCELLULAR LOCATION: Isoform p56: Nucleus, nucleolus. Cytoplasm. SUBCELLULAR LOCATION: Isoform p30: Cytoplasm. TISSUE SPECIFICITY: Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis. INDUCTION: By type I interferon (IFN) and viruses. DOMAIN: The ubiquitin-like domains are essential for its antiviral activity. SIMILARITY: Belongs to the 2-5A synthase family. SIMILARITY: Contains 2 ubiquitin-like domains. CAUTION: This is the ortholog of mouse OASL1. SEQUENCE CAUTION: Sequence=AAC41733.1; Type=Frameshift; Positions=386;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15646
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
