ID:MPP8_HUMAN DESCRIPTION: RecName: Full=M-phase phosphoprotein 8; AltName: Full=Two hybrid-associated protein 3 with RanBPM; Short=Twa3; FUNCTION: Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression. SUBUNIT: Homodimer. Interacts (via chromo domain) with histone H3K9me3. Has the highest affinity for H3K9me3, and lesser affinity for H3K9me2 and H3K9me1. Interacts with DNMT3, EHMT1 and SETDB1. SUBCELLULAR LOCATION: Nucleus. Note=Detected on heterochromatin. Detected on nucleosomes. DOMAIN: The chromo domain mediates interaction with methylated 'Lys-9' of histone H3 (H3K9me), with the highest affinity for the trimethylated form (H3K9me3). PTM: Phosphorylated in M (mitotic) phase. SIMILARITY: Contains 4 ANK repeats. SIMILARITY: Contains 1 chromo domain. SEQUENCE CAUTION: Sequence=AAH46214.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB71284.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI46172.1; Type=Frameshift; Positions=248, 255, 731;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99549
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004842 ubiquitin-protein transferase activity GO:0005515 protein binding GO:0031625 ubiquitin protein ligase binding GO:0035064 methylated histone binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0016567 protein ubiquitination GO:0044030 regulation of DNA methylation GO:0045892 negative regulation of transcription, DNA-templated
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