Human Gene TMEM260 (ENST00000261556.11) from GENCODE V43
  Description: Homo sapiens transmembrane protein 260 (TMEM260), mRNA. (from RefSeq NM_017799)
Gencode Transcript: ENST00000261556.11
Gencode Gene: ENSG00000070269.14
Transcript (Including UTRs)
   Position: hg38 chr14:56,579,798-56,649,515 Size: 69,718 Total Exon Count: 16 Strand: +
Coding Region
   Position: hg38 chr14:56,579,915-56,647,497 Size: 67,583 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-02-17 13:02:02

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr14:56,579,798-56,649,515)mRNA (may differ from genome)Protein (707 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=UPF0679 protein C14orf101;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the UPF0679 family.
SEQUENCE CAUTION: Sequence=BAA91139.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BC045556; Type=Frameshift; Positions=212;

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  MalaCards Disease Associations
  MalaCards Gene Search: TMEM260
Diseases sorted by gene-association score: structural heart defects and renal anomalies syndrome* (900)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.95 RPKM in Ovary
Total median expression: 78.36 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -45.30117-0.387 Picture PostScript Text
3' UTR -514.302018-0.255 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021280 - DUF2723

Pfam Domains:
PF11028 - Protein of unknown function (DUF2723)

ModBase Predicted Comparative 3D Structure on Q9NX78
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  BX647387 - Homo sapiens mRNA; cDNA DKFZp686C23144 (from clone DKFZp686C23144).
AK056291 - Homo sapiens cDNA FLJ31729 fis, clone NT2RI2006825.
AK293099 - Homo sapiens cDNA FLJ78265 complete cds.
AK295989 - Homo sapiens cDNA FLJ61292 complete cds.
BC008949 - Homo sapiens chromosome 14 open reading frame 101, mRNA (cDNA clone IMAGE:3028907).
BC023579 - Homo sapiens chromosome 14 open reading frame 101, mRNA (cDNA clone IMAGE:3533240).
BC121163 - Homo sapiens chromosome 14 open reading frame 101, mRNA (cDNA clone MGC:150505 IMAGE:40121557), complete cds.
BC121164 - Homo sapiens chromosome 14 open reading frame 101, mRNA (cDNA clone IMAGE:40121560), partial cds.
AK000399 - Homo sapiens cDNA FLJ20392 fis, clone KAIA4653.
AK023885 - Homo sapiens cDNA FLJ13823 fis, clone THYRO1000502.
BC045556 - Homo sapiens cDNA clone IMAGE:4791744, containing frame-shift errors.
AK309920 - Homo sapiens cDNA, FLJ99961.
KJ902716 - Synthetic construct Homo sapiens clone ccsbBroadEn_12110 C14orf101 gene, encodes complete protein.
JD369824 - Sequence 350848 from Patent EP1572962.
JD303158 - Sequence 284182 from Patent EP1572962.
JD443790 - Sequence 424814 from Patent EP1572962.
JD194794 - Sequence 175818 from Patent EP1572962.
JD546968 - Sequence 527992 from Patent EP1572962.
JD047178 - Sequence 28202 from Patent EP1572962.
JD074322 - Sequence 55346 from Patent EP1572962.
JD108252 - Sequence 89276 from Patent EP1572962.
JD036439 - Sequence 17463 from Patent EP1572962.
JD415521 - Sequence 396545 from Patent EP1572962.
JD314073 - Sequence 295097 from Patent EP1572962.
JD304066 - Sequence 285090 from Patent EP1572962.
JD026294 - Sequence 7318 from Patent EP1572962.
JD035926 - Sequence 16950 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8KAN4, B3KPF5, C14orf101, CN101_HUMAN, ENST00000261556.1, ENST00000261556.10, ENST00000261556.2, ENST00000261556.3, ENST00000261556.4, ENST00000261556.5, ENST00000261556.6, ENST00000261556.7, ENST00000261556.8, ENST00000261556.9, NM_017799, Q86XE1, Q9NX78, uc001xcm.1, uc001xcm.2, uc001xcm.3, uc001xcm.4, uc001xcm.5
UCSC ID: ENST00000261556.11
RefSeq Accession: NM_017799
Protein: Q9NX78 (aka CN101_HUMAN or CNA1_HUMAN)
CCDS: CCDS9727.2

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.