Human Gene HSPA2 (ENST00000394709.2) from GENCODE V44
Description: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. (from UniProt P54652) Gencode Transcript: ENST00000394709.2 Gencode Gene: ENSG00000126803.10 Transcript (Including UTRs) Position: hg38 chr14:64,535,905-64,546,173 Size: 10,269 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr14:64,540,850-64,542,769 Size: 1,920 Coding Exon Count: 1
ID:HSP72_HUMAN DESCRIPTION: RecName: Full=Heat shock-related 70 kDa protein 2; Short=Heat shock 70 kDa protein 2; FUNCTION: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. SUBUNIT: Interacts with ZNF541. Component of the CatSper complex (By similarity). INTERACTION: Q9NZL4:HSPBP1; NbExp=3; IntAct=EBI-356991, EBI-356763; SIMILARITY: Belongs to the heat shock protein 70 family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/hspa2/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P54652
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001934 positive regulation of protein phosphorylation GO:0006986 response to unfolded protein GO:0007140 male meiosis GO:0007141 male meiosis I GO:0007283 spermatogenesis GO:0007286 spermatid development GO:0009408 response to heat GO:0009409 response to cold GO:0010971 positive regulation of G2/M transition of mitotic cell cycle GO:0030154 cell differentiation GO:0032781 positive regulation of ATPase activity GO:0042026 protein refolding GO:0070194 synaptonemal complex disassembly GO:0090084 negative regulation of inclusion body assembly GO:1901896 positive regulation of calcium-transporting ATPase activity
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