Human Gene CALML4 (ENST00000540479.6) from GENCODE V44
  Description: Homo sapiens calmodulin like 4 (CALML4), transcript variant 4, mRNA. (from RefSeq NM_001286695)
Gencode Transcript: ENST00000540479.6
Gencode Gene: ENSG00000129007.16
Transcript (Including UTRs)
   Position: hg38 chr15:68,190,705-68,205,298 Size: 14,594 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg38 chr15:68,194,015-68,197,587 Size: 3,573 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:68,190,705-68,205,298)mRNA (may differ from genome)Protein (81 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCMalacardsMGIneXtProtPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CALL4_HUMAN
DESCRIPTION: RecName: Full=Calmodulin-like protein 4; AltName: Full=Serologically defined breast cancer antigen NY-BR-20;
TISSUE SPECIFICITY: Expressed in breast cancer cell lines.
SIMILARITY: Belongs to the calmodulin family.
SIMILARITY: Contains 4 EF-hand domains.
SEQUENCE CAUTION: Sequence=AAG48255.1; Type=Frameshift; Positions=Several; Sequence=BAG59377.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.53 RPKM in Colon - Transverse
Total median expression: 88.46 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -30.1095-0.317 Picture PostScript Text
3' UTR -936.403310-0.283 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011992 - EF-hand-like_dom
IPR018249 - EF_HAND_2
IPR002048 - EF_hand_Ca-bd

ModBase Predicted Comparative 3D Structure on Q96GE6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005509 calcium ion binding


-  Descriptions from all associated GenBank mRNAs
  BX640702 - Homo sapiens mRNA; cDNA DKFZp686A09136 (from clone DKFZp686A09136).
BC015215 - Homo sapiens calmodulin-like 4, mRNA (cDNA clone IMAGE:3849408), partial cds.
BX640817 - Homo sapiens mRNA; cDNA DKFZp686D05174 (from clone DKFZp686D05174).
AK092628 - Homo sapiens cDNA FLJ35309 fis, clone PROST2010219, weakly similar to CALMODULIN.
AX747637 - Sequence 1162 from Patent EP1308459.
BC009516 - Homo sapiens calmodulin-like 4, mRNA (cDNA clone IMAGE:3546033).
AF308287 - Homo sapiens serologically defined breast cancer antigen NY-BR-20 mRNA, partial cds.
AK296804 - Homo sapiens cDNA FLJ60655 complete cds, highly similar to Homo sapiens calmodulin-like 4 (CALML4), transcript variant 1, mRNA.
KJ903576 - Synthetic construct Homo sapiens clone ccsbBroadEn_12970 CALML4 gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DL15, CALL4_HUMAN, ENST00000540479.1, ENST00000540479.2, ENST00000540479.3, ENST00000540479.4, ENST00000540479.5, NM_001286695, Q6N048, Q96GE6, Q9H286, uc002ard.1, uc002ard.2, uc002ard.3, uc002ard.4, uc002ard.5, uc002ard.6
UCSC ID: ENST00000540479.6
RefSeq Accession: NM_001286695
Protein: Q96GE6 (aka CALL4_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.