ID:DET1_HUMAN DESCRIPTION: RecName: Full=DET1 homolog; AltName: Full=De-etiolated-1 homolog; FUNCTION: Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation. SUBUNIT: Component of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1, DET1, DDB1, CUL4A and COP1. SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Highly expressed in the ovary, some lymphoid organs and resting leukocytes. SIMILARITY: Belongs to the DET1 family. SEQUENCE CAUTION: Sequence=BAA91447.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF09737 - De-etiolated protein 1 Det1
ModBase Predicted Comparative 3D Structure on Q7L5Y6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0031625 ubiquitin protein ligase binding GO:0044877 macromolecular complex binding GO:1990756 protein binding, bridging involved in substrate recognition for ubiquitination
Biological Process: GO:0016567 protein ubiquitination GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0065003 macromolecular complex assembly
BC073867 - Homo sapiens de-etiolated homolog 1 (Arabidopsis), mRNA (cDNA clone IMAGE:5499012). BC001242 - Homo sapiens de-etiolated homolog 1 (Arabidopsis), mRNA (cDNA clone IMAGE:3451902), partial cds. BC064591 - Homo sapiens de-etiolated homolog 1 (Arabidopsis), mRNA (cDNA clone IMAGE:5747683). AB073887 - Homo sapiens primary neuroblastoma cDNA, clone:Nbla02975, full insert sequence. AK000965 - Homo sapiens cDNA FLJ10103 fis, clone HEMBA1002495, weakly similar to LIGHT-MEDIATED DEVELOPMENT PROTEIN DET1. AK054603 - Homo sapiens cDNA FLJ30041 fis, clone 3NB692001528, highly similar to DET1 homolog. JD440828 - Sequence 421852 from Patent EP1572962. JD553278 - Sequence 534302 from Patent EP1572962. JD163146 - Sequence 144170 from Patent EP1572962. JD299626 - Sequence 280650 from Patent EP1572962. JD563330 - Sequence 544354 from Patent EP1572962. JD204917 - Sequence 185941 from Patent EP1572962. JD277112 - Sequence 258136 from Patent EP1572962. JD369562 - Sequence 350586 from Patent EP1572962. JD248445 - Sequence 229469 from Patent EP1572962. JD414206 - Sequence 395230 from Patent EP1572962. JD083777 - Sequence 64801 from Patent EP1572962. BC109060 - Homo sapiens de-etiolated homolog 1 (Arabidopsis), mRNA (cDNA clone MGC:126156 IMAGE:40033727), complete cds. BC109061 - Homo sapiens de-etiolated homolog 1 (Arabidopsis), mRNA (cDNA clone MGC:126157 IMAGE:40033728), complete cds. JD528730 - Sequence 509754 from Patent EP1572962. JD319038 - Sequence 300062 from Patent EP1572962. JD272441 - Sequence 253465 from Patent EP1572962. JD316273 - Sequence 297297 from Patent EP1572962. KJ894121 - Synthetic construct Homo sapiens clone ccsbBroadEn_03515 DET1 gene, encodes complete protein. JD264803 - Sequence 245827 from Patent EP1572962. JD087926 - Sequence 68950 from Patent EP1572962. JD320228 - Sequence 301252 from Patent EP1572962. JD548866 - Sequence 529890 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04120 - Ubiquitin mediated proteolysis
Reactome (by CSHL, EBI, and GO)
Protein Q7L5Y6 (Reactome details) participates in the following event(s):
R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-983147 Release of E3 from polyubiquitinated substrate R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System
US Server
