Human Gene CRTC3 (ENST00000268184.11) from GENCODE V44
Description: Homo sapiens CREB regulated transcription coactivator 3 (CRTC3), transcript variant 1, mRNA. (from RefSeq NM_022769) RefSeq Summary (NM_022769): This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]. Gencode Transcript: ENST00000268184.11 Gencode Gene: ENSG00000140577.17 Transcript (Including UTRs) Position: hg38 chr15:90,529,923-90,645,345 Size: 115,423 Total Exon Count: 15 Strand: + Coding Region Position: hg38 chr15:90,530,072-90,642,140 Size: 112,069 Coding Exon Count: 15
ID:CRTC3_HUMAN DESCRIPTION: RecName: Full=CREB-regulated transcription coactivator 3; AltName: Full=Transducer of regulated cAMP response element-binding protein 3; Short=TORC-3; Short=Transducer of CREB protein 3; FUNCTION: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). SUBUNIT: Binding, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 enhances recruitment of TAF4 to the promoter. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction (By similarity). Interaction with HTLV-1 TAX enhances its transcriptional activity. Interacts, via the N- terminal with the ankyrin repeats of BCL3, to form a complex with CREB1 on CRE and TxRE responsive elements and represses HTLV-1 LTR-mediated transcription. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Appears to be mainly nuclear. TISSUE SPECIFICITY: Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach. SIMILARITY: Belongs to the TORC family. SEQUENCE CAUTION: Sequence=BAC03424.1; Type=Frameshift; Positions=82;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF12886 - Transducer of regulated CREB activity, C terminus PF12885 - Transducer of regulated CREB activity middle domain PF12884 - Transducer of regulated CREB activity, N terminus
ModBase Predicted Comparative 3D Structure on Q6UUV7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0008140 cAMP response element binding protein binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0016032 viral process GO:0032793 positive regulation of CREB transcription factor activity GO:0042116 macrophage activation GO:0043951 negative regulation of cAMP-mediated signaling GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0050995 negative regulation of lipid catabolic process GO:0051289 protein homotetramerization GO:0097009 energy homeostasis
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