Human Gene NAE1 (ENST00000290810.8) from GENCODE V44
Description: Homo sapiens NEDD8 activating enzyme E1 subunit 1 (NAE1), transcript variant 1, mRNA. (from RefSeq NM_003905) RefSeq Summary (NM_003905): The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000290810.8 Gencode Gene: ENSG00000159593.15 Transcript (Including UTRs) Position: hg38 chr16:66,802,878-66,830,976 Size: 28,099 Total Exon Count: 20 Strand: - Coding Region Position: hg38 chr16:66,803,009-66,830,899 Size: 27,891 Coding Exon Count: 20
ID:ULA1_HUMAN DESCRIPTION: RecName: Full=NEDD8-activating enzyme E1 regulatory subunit; AltName: Full=Amyloid beta precursor protein-binding protein 1, 59 kDa; Short=APP-BP1; AltName: Full=Amyloid protein-binding protein 1; AltName: Full=Proto-oncogene protein 1; FUNCTION: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. ENZYME REGULATION: Binding of TP53BP2 to the regulatory subunit NAE1 decreases neddylation activity. PATHWAY: Protein modification; protein neddylation. SUBUNIT: Heterodimer of UBA3 and NAE1. The complex binds NEDD8 and UBE2M. Binds APP and TP53BP2. SUBCELLULAR LOCATION: Cell membrane. Note=Colocalizes with APP in lipid rafts. TISSUE SPECIFICITY: Ubiquitous in fetal tissues. Expressed throughout the adult brain. PTM: Ubiquitinated by TRIP12, leading to its degradation by the proteasome. MISCELLANEOUS: NAE1 and UBA3 correspond to the N-terminal and the C-terminal part of yeast UBA3. In yeast the two subunits form a single polypeptide chain. SIMILARITY: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13564
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0008641 small protein activating enzyme activity GO:0019781 NEDD8 activating enzyme activity GO:0031625 ubiquitin protein ligase binding GO:0046982 protein heterodimerization activity
US Server
