Human Gene PIGL (ENST00000225609.10) from GENCODE V44
Description: Homo sapiens phosphatidylinositol glycan anchor biosynthesis class L (PIGL), mRNA. (from RefSeq NM_004278) RefSeq Summary (NM_004278): This gene encodes an enzyme that catalyzes the second step of glycosylphosphatidylinositol (GPI) biosynthesis, which is the de-N-acetylation of N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI). Study of a similar rat enzyme suggests that this protein localizes to the endoplasmic reticulum. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000225609.10 Gencode Gene: ENSG00000108474.17 Transcript (Including UTRs) Position: hg38 chr17:16,217,210-16,326,411 Size: 109,202 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr17:16,217,227-16,325,898 Size: 108,672 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y2B2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.