Human Gene KRT38 (ENST00000246646.4) from GENCODE V44
  Description: Homo sapiens keratin 38 (KRT38), mRNA. (from RefSeq NM_006771)
RefSeq Summary (NM_006771): The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Gencode Transcript: ENST00000246646.4
Gencode Gene: ENSG00000171360.4
Transcript (Including UTRs)
   Position: hg38 chr17:41,436,154-41,440,983 Size: 4,830 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg38 chr17:41,437,412-41,440,921 Size: 3,510 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:41,436,154-41,440,983)mRNA (may differ from genome)Protein (456 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KRT38_HUMAN
DESCRIPTION: RecName: Full=Keratin, type I cuticular Ha8; AltName: Full=Hair keratin, type I Ha8; AltName: Full=Keratin-38; Short=K38;
MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
SIMILARITY: Belongs to the intermediate filament family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.04 RPKM in Vagina
Total median expression: 0.27 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -12.6062-0.203 Picture PostScript Text
3' UTR -349.701258-0.278 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016044 - F
IPR001664 - IF
IPR018039 - Intermediate_filament_CS
IPR002957 - Keratin_I

Pfam Domains:
PF00038 - Intermediate filament protein

ModBase Predicted Comparative 3D Structure on O76015
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005198 structural molecule activity
GO:0005515 protein binding

Biological Process:
GO:0031424 keratinization
GO:0070268 cornification

Cellular Component:
GO:0005829 cytosol
GO:0005882 intermediate filament
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  JD544578 - Sequence 525602 from Patent EP1572962.
JD220355 - Sequence 201379 from Patent EP1572962.
JD226730 - Sequence 207754 from Patent EP1572962.
JD136503 - Sequence 117527 from Patent EP1572962.
BC131715 - Homo sapiens keratin 38, mRNA (cDNA clone MGC:150589 IMAGE:40123079), complete cds.
JD541807 - Sequence 522831 from Patent EP1572962.
JD367991 - Sequence 349015 from Patent EP1572962.
JD097903 - Sequence 78927 from Patent EP1572962.
JD290438 - Sequence 271462 from Patent EP1572962.
JD548709 - Sequence 529733 from Patent EP1572962.
JD162618 - Sequence 143642 from Patent EP1572962.
JD358017 - Sequence 339041 from Patent EP1572962.
JD092672 - Sequence 73696 from Patent EP1572962.
JD316843 - Sequence 297867 from Patent EP1572962.
JD270996 - Sequence 252020 from Patent EP1572962.
JD521891 - Sequence 502915 from Patent EP1572962.
JD048360 - Sequence 29384 from Patent EP1572962.
JD161165 - Sequence 142189 from Patent EP1572962.
AJ786656 - Homo sapiens partial mRNA for hHa8 protein (KRTHA8 gene).
JD468791 - Sequence 449815 from Patent EP1572962.
KJ897892 - Synthetic construct Homo sapiens clone ccsbBroadEn_07286 KRT38 gene, encodes complete protein.
JD347351 - Sequence 328375 from Patent EP1572962.
JD205061 - Sequence 186085 from Patent EP1572962.
JD277233 - Sequence 258257 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O76015 (Reactome details) participates in the following event(s):

R-HSA-6805546 Keratin type I binds keratin type II
R-HSA-6805573 Keratin type I/type II heterodimers form tetramers
R-HSA-6806613 Keratin tetramers bind to form unit length filaments
R-HSA-6805567 Keratinization
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: A2RRM5, ENST00000246646.1, ENST00000246646.2, ENST00000246646.3, HHA8, HKA8, KRT38_HUMAN, KRTHA8, NM_006771, O76015, Q6A164, uc002hwq.1, uc002hwq.2, uc002hwq.3
UCSC ID: ENST00000246646.4
RefSeq Accession: NM_006771
Protein: O76015 (aka KRT38_HUMAN)
CCDS: CCDS11392.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.