Human Gene ICAM2 (ENST00000418105.5) from GENCODE V44
Description: Homo sapiens intercellular adhesion molecule 2 (ICAM2), transcript variant 2, mRNA. (from RefSeq NM_001099787) RefSeq Summary (NM_001099787): The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000418105.5 Gencode Gene: ENSG00000108622.11 Transcript (Including UTRs) Position: hg38 chr17:64,002,596-64,020,634 Size: 18,039 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr17:64,002,747-64,006,691 Size: 3,945 Coding Exon Count: 4
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6FHE2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCarta from NCI Cancer Genome Anatomy Project h_granulocytesPathway - Adhesion and Diapedesis of Granulocytes h_lympathway - Adhesion and Diapedesis of Lymphocytes
US Server
