Human Gene CREB3L3 (ENST00000078445.7) from GENCODE V44
Description: Homo sapiens cAMP responsive element binding protein 3 like 3 (CREB3L3), transcript variant 1, mRNA. (from RefSeq NM_032607) RefSeq Summary (NM_032607): This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]. Gencode Transcript: ENST00000078445.7 Gencode Gene: ENSG00000060566.14 Transcript (Including UTRs) Position: hg38 chr19:4,153,631-4,173,054 Size: 19,424 Total Exon Count: 10 Strand: + Coding Region Position: hg38 chr19:4,153,748-4,171,969 Size: 18,222 Coding Exon Count: 10
ID:CR3L3_HUMAN DESCRIPTION: RecName: Full=Cyclic AMP-responsive element-binding protein 3-like protein 3; Short=cAMP-responsive element-binding protein 3-like protein 3; AltName: Full=Transcription factor CREB-H; Contains: RecName: Full=Processed cyclic AMP-responsive element-binding protein 3-like protein 3; FUNCTION: Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. SUBUNIT: Binds DNA as a dimer (By similarity). Probably homodimerizes. Probably forms a heterodimer with ATF6. Interacts with ATF6. INTERACTION: P18850:ATF6; NbExp=2; IntAct=EBI-852194, EBI-852157; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: Processed cyclic AMP-responsive element- binding protein 3-like protein 3: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. TISSUE SPECIFICITY: Exclusively expressed in liver. Underexpressed in hepatocellular carcinoma tissues. PTM: Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PTM: N- and O-glycosylated. N-glycosylation is required for optimal proteolytic activation. O-glycosylated with core 1 or possibly core 8 glycans. SIMILARITY: Belongs to the bZIP family. ATF subfamily. SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain. SEQUENCE CAUTION: Sequence=BAD18804.1; Type=Frameshift; Positions=445; Sequence=BAD18804.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q68CJ9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000976 transcription regulatory region sequence-specific DNA binding GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0035497 cAMP response element binding GO:0042803 protein homodimerization activity GO:0046982 protein heterodimerization activity
Biological Process: GO:0002675 positive regulation of acute inflammatory response GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006986 response to unfolded protein GO:0030968 endoplasmic reticulum unfolded protein response GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
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