Human Gene RFX2 (ENST00000303657.10) from GENCODE V44
Description: Homo sapiens regulatory factor X2 (RFX2), transcript variant 1, mRNA. (from RefSeq NM_000635) RefSeq Summary (NM_000635): This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000303657.10 Gencode Gene: ENSG00000087903.13 Transcript (Including UTRs) Position: hg38 chr19:5,993,164-6,110,500 Size: 117,337 Total Exon Count: 18 Strand: - Coding Region Position: hg38 chr19:5,994,835-6,047,496 Size: 52,662 Coding Exon Count: 17
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P48378
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding
Biological Process: GO:0001675 acrosome assembly GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007283 spermatogenesis GO:0007286 spermatid development GO:0030030 cell projection organization GO:0030154 cell differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0060271 cilium assembly GO:1990830 cellular response to leukemia inhibitory factor
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