Human Gene CDKN2D (ENST00000393599.3) from GENCODE V44
Description: Homo sapiens cyclin dependent kinase inhibitor 2D (CDKN2D), transcript variant 2, mRNA. (from RefSeq NM_079421) RefSeq Summary (NM_001800): The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000393599.3 Gencode Gene: ENSG00000129355.7 Transcript (Including UTRs) Position: hg38 chr19:10,566,460-10,568,979 Size: 2,520 Total Exon Count: 2 Strand: - Coding Region Position: hg38 chr19:10,567,058-10,568,653 Size: 1,596 Coding Exon Count: 2
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P55273
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0005515 protein binding GO:0019901 protein kinase binding
Biological Process: GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000082 G1/S transition of mitotic cell cycle GO:0000731 DNA synthesis involved in DNA repair GO:0007049 cell cycle GO:0007050 cell cycle arrest GO:0007605 sensory perception of sound GO:0008285 negative regulation of cell proliferation GO:0009411 response to UV GO:0030308 negative regulation of cell growth GO:0031658 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0032526 response to retinoic acid GO:0033280 response to vitamin D GO:0042326 negative regulation of phosphorylation GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0048102 autophagic cell death GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902807 negative regulation of cell cycle G1/S phase transition
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