Human Gene KIRREL2 (ENST00000360202.10) from GENCODE V44
Description: Homo sapiens kirre like nephrin family adhesion molecule 2 (KIRREL2), transcript variant 3, mRNA. (from RefSeq NM_199180) RefSeq Summary (NM_199180): This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin (GeneID: 527362) are regulated by a bidirectional promoter. [provided by RefSeq, Jul 2016]. Gencode Transcript: ENST00000360202.10 Gencode Gene: ENSG00000126259.20 Transcript (Including UTRs) Position: hg38 chr19:35,856,911-35,867,136 Size: 10,226 Total Exon Count: 15 Strand: + Coding Region Position: hg38 chr19:35,857,120-35,866,492 Size: 9,373 Coding Exon Count: 15
ID:KIRR2_HUMAN DESCRIPTION: RecName: Full=Kin of IRRE-like protein 2; AltName: Full=Kin of irregular chiasm-like protein 2; AltName: Full=Nephrin-like protein 3; Flags: Precursor; SUBUNIT: Interacts with NPHS2/podocin (via the C-terminus). Interacts with NPHS1 (via the Ig-like domains) (By similarity). SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (Potential). TISSUE SPECIFICITY: Highly expressed in beta-cells of the pancreatic islets. SIMILARITY: Belongs to the immunoglobulin superfamily. SIMILARITY: Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6UWL6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
