Human Gene FGF21 (ENST00000593756.6) from GENCODE V44
Description: Homo sapiens fibroblast growth factor 21 (FGF21), mRNA. (from RefSeq NM_019113) RefSeq Summary (NM_019113): Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue. [provided by RefSeq, Mar 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000593756.6 Gencode Gene: ENSG00000105550.10 Transcript (Including UTRs) Position: hg38 chr19:48,755,524-48,758,330 Size: 2,807 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr19:48,756,237-48,758,220 Size: 1,984 Coding Exon Count: 3
ID:FGF21_HUMAN DESCRIPTION: RecName: Full=Fibroblast growth factor 21; Short=FGF-21; Flags: Precursor; FUNCTION: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. SUBUNIT: Interacts (via C-terminus) with KLB; this interaction is direct. Interacts with FGFR4. SUBCELLULAR LOCATION: Secreted (Potential). SIMILARITY: Belongs to the heparin-binding growth factors family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/fgf21/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NSA1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC018404 - Homo sapiens fibroblast growth factor 21, mRNA (cDNA clone MGC:21502 IMAGE:3881069), complete cds. AY359086 - Homo sapiens clone DNA144841 FGF21 (UNQ3115) mRNA, complete cds. AB590410 - Synthetic construct DNA, clone: pFN21AE1420, Homo sapiens FGF21 gene for fibroblast growth factor 21, without stop codon, in Flexi system. DQ891786 - Synthetic construct clone IMAGE:100004416; FLH179904.01X; RZPDo839D10132D fibroblast growth factor 21 (FGF21) gene, encodes complete protein. DQ894970 - Synthetic construct Homo sapiens clone IMAGE:100009430; FLH179900.01L; RZPDo839D10131D fibroblast growth factor 21 (FGF21) gene, encodes complete protein. AB021975 - Homo sapiens mRNA for FGF-21, complete cds. FZ414866 - WO 2011010706-A/26: FGF21 cis-element binding substance. JC201587 - Sequence 26 from Patent EP2458005.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04010 - MAPK signaling pathway hsa04810 - Regulation of actin cytoskeleton hsa05200 - Pathways in cancer hsa05218 - Melanoma
Reactome (by CSHL, EBI, and GO)
Protein Q9NSA1 (Reactome details) participates in the following event(s):
R-HSA-8963889 Assembly of active LPL and LIPC lipase complexes R-HSA-8963899 Plasma lipoprotein remodeling R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance R-HSA-382551 Transport of small molecules
US Server
