Human Gene COX7A2L (ENST00000378669.5) from GENCODE V44
Description: Homo sapiens cytochrome c oxidase subunit 7A2 like (COX7A2L), transcript variant 2, mRNA. (from RefSeq NM_001319036) RefSeq Summary (NM_004718): Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]. Gencode Transcript: ENST00000378669.5 Gencode Gene: ENSG00000115944.15 Transcript (Including UTRs) Position: hg38 chr2:42,349,338-42,369,010 Size: 19,673 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr2:42,351,219-42,361,161 Size: 9,943 Coding Exon Count: 3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF02238 - Cytochrome c oxidase subunit VII
ModBase Predicted Comparative 3D Structure on Q6FGA0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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