Human Gene GPR75 (ENST00000394705.3) from GENCODE V44
Description: Homo sapiens G protein-coupled receptor 75 (GPR75), mRNA. (from RefSeq NM_006794) RefSeq Summary (NM_006794): GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand.[supplied by OMIM, Jul 2002]. Gencode Transcript: ENST00000394705.3 Gencode Gene: ENSG00000119737.6 Transcript (Including UTRs) Position: hg38 chr2:53,852,912-53,859,967 Size: 7,056 Total Exon Count: 2 Strand: - Coding Region Position: hg38 chr2:53,853,134-53,854,756 Size: 1,623 Coding Exon Count: 1
ID:GPR75_HUMAN DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 75; FUNCTION: Orphan receptor. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer. SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95800
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.