Human Gene BMPR2 (ENST00000374580.10) from GENCODE V41
  Description: Homo sapiens bone morphogenetic protein receptor type 2 (BMPR2), mRNA. (from RefSeq NM_001204)
RefSeq Summary (NM_001204): This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, May 2020]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Gencode Transcript: ENST00000374580.10
Gencode Gene: ENSG00000204217.16
Transcript (Including UTRs)
   Position: hg38 chr2:202,376,327-202,567,749 Size: 191,423 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg38 chr2:202,377,475-202,559,946 Size: 182,472 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesGeneReviewsMethods
Data last updated at UCSC: 2022-05-14 09:57:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:202,376,327-202,567,749)mRNA (may differ from genome)Protein (1038 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSCGAPEnsemblEntrez GeneExonPrimerGencode
GeneCardsHGNCHPRDLynxMGImyGene2
neXtProtOMIMPubMedReactomeUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: BMPR2_HUMAN
DESCRIPTION: RecName: Full=Bone morphogenetic protein receptor type-2; Short=BMP type-2 receptor; Short=BMPR-2; EC=2.7.11.30; AltName: Full=Bone morphogenetic protein receptor type II; Short=BMP type II receptor; Short=BMPR-II; Flags: Precursor;
FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor- protein] phosphate.
COFACTOR: Magnesium or manganese (By similarity).
INTERACTION: P08607:C4bpa (xeno); NbExp=3; IntAct=EBI-527196, EBI-527325; P68404:Prkcb (xeno); NbExp=4; IntAct=EBI-527196, EBI-397048;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Highly expressed in heart and liver.
DISEASE: Defects in BMPR2 are the cause of primary pulmonary hypertension (PPH1) [MIM:178600]. PPH1 is a rare autosomal dominant disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial PPH1 is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.
DISEASE: Defects in BMPR2 are a cause of pulmonary venoocclusive disease (PVOD) [MIM:265450]. PVOD is a rare form of pulmonary hypertension in which the vascular changes originate in the small pulmonary veins and venules. The pathogenesis is unknown and any link with PPH1 has been speculative. The finding of PVOD associated with a BMPR2 mutation reveals a possible pathogenetic connection with PPH1.
SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
SIMILARITY: Contains 1 protein kinase domain.
WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/BMPR2";

-  MalaCards Disease Associations
  MalaCards Gene Search: BMPR2
Diseases sorted by gene-association score: pulmonary hypertension, familial primary, 1, with or without hht* (1200), pulmonary venoocclusive disease 1* (1044), pulmonary hypertension* (501), heritable pulmonary arterial hypertension* (469), pulmonary venoocclusive disease* (436), hereditary hemorrhagic telangiectasia (16), mixed connective tissue disease (15), chronic pulmonary heart disease (13), connective tissue disease (12), telangiectasis (11), chronic thromboembolic pulmonary hypertension (11), multiple synostoses syndrome (8), portal hypertension (8), arteriovenous malformation (8), eisenmenger syndrome (7), heart disease (4), vascular disease (3)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.36 RPKM in Lung
Total median expression: 385.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -474.601148-0.413 Picture PostScript Text
3' UTR -1733.447803-0.222 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000472 - Activin_rcpt
IPR015770 - BMPRII
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS

Pfam Domains:
PF01064 - Activin types I and II receptor domain
PF00069 - Protein kinase domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2HLQ - X-ray 3G2F - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q13873
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsembl  
Protein SequenceProtein SequenceProtein SequenceProtein Sequence  
AlignmentAlignmentAlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016362 activin receptor activity, type II
GO:0016740 transferase activity
GO:0019838 growth factor binding
GO:0036122 BMP binding
GO:0046872 metal ion binding
GO:0098821 BMP receptor activity

Biological Process:
GO:0001707 mesoderm formation
GO:0001893 maternal placenta development
GO:0001935 endothelial cell proliferation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001946 lymphangiogenesis
GO:0001974 blood vessel remodeling
GO:0002063 chondrocyte development
GO:0003085 negative regulation of systemic arterial blood pressure
GO:0003148 outflow tract septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003183 mitral valve morphogenesis
GO:0003186 tricuspid valve morphogenesis
GO:0003197 endocardial cushion development
GO:0003252 negative regulation of cell proliferation involved in heart valve morphogenesis
GO:0006366 transcription from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007420 brain development
GO:0009267 cellular response to starvation
GO:0009952 anterior/posterior pattern specification
GO:0010595 positive regulation of endothelial cell migration
GO:0010634 positive regulation of epithelial cell migration
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014916 regulation of lung blood pressure
GO:0016310 phosphorylation
GO:0030166 proteoglycan biosynthetic process
GO:0030308 negative regulation of cell growth
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0032924 activin receptor signaling pathway
GO:0042127 regulation of cell proliferation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045778 positive regulation of ossification
GO:0045906 negative regulation of vasoconstriction
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048286 lung alveolus development
GO:0048842 positive regulation of axon extension involved in axon guidance
GO:0060041 retina development in camera-type eye
GO:0060173 limb development
GO:0060350 endochondral bone morphogenesis
GO:0060412 ventricular septum morphogenesis
GO:0060413 atrial septum morphogenesis
GO:0060836 lymphatic endothelial cell differentiation
GO:0060840 artery development
GO:0060841 venous blood vessel development
GO:0061036 positive regulation of cartilage development
GO:0061298 retina vasculature development in camera-type eye
GO:0061626 pharyngeal arch artery morphogenesis
GO:0071773 cellular response to BMP stimulus
GO:0072577 endothelial cell apoptotic process
GO:1902731 negative regulation of chondrocyte proliferation
GO:1905314 semi-lunar valve development
GO:2000279 negative regulation of DNA biosynthetic process
GO:0003181 atrioventricular valve morphogenesis
GO:0048738 cardiac muscle tissue development

Cellular Component:
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0005913 cell-cell adherens junction
GO:0009925 basal plasma membrane
GO:0009986 cell surface
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0044214 spanning component of plasma membrane


-  Descriptions from all associated GenBank mRNAs
  KJ890775 - Synthetic construct Homo sapiens clone ccsbBroadEn_00169 BMPR2 gene, encodes complete protein.
KJ905150 - Synthetic construct Homo sapiens clone ccsbBroadEn_14551 BMPR2 gene, encodes complete protein.
LF205213 - JP 2014500723-A/12716: Polycomb-Associated Non-Coding RNAs.
MA440790 - JP 2018138019-A/12716: Polycomb-Associated Non-Coding RNAs.
LF383610 - JP 2014500723-A/191113: Polycomb-Associated Non-Coding RNAs.
MA619187 - JP 2018138019-A/191113: Polycomb-Associated Non-Coding RNAs.
BC011622 - Homo sapiens cDNA clone IMAGE:4026085, **** WARNING: chimeric clone ****.
BC052985 - Homo sapiens bone morphogenetic protein receptor, type II (serine/threonine kinase), mRNA (cDNA clone MGC:60135 IMAGE:6149698), complete cds.
AK292430 - Homo sapiens cDNA FLJ76945 complete cds, highly similar to Homo sapiens bone morphogenetic protein receptor, type II(serine/threonine kinase) (BMPR2), transcript variant 1, mRNA.
D50516 - Homo sapiens mRNA for type II receptor for bone morphogenetic protein-4, complete cds.
Z48923 - H.sapiens mRNA for BMPR-II.
U25110 - Human bone morphogenic protein type II receptor mRNA, complete cds.
U20165 - Human type II serine/threonine kinase receptor mRNA, complete cds.
MH191353 - UNVERIFIED: Homo sapiens cell line ThESC bone morphogenic protein type II receptor-like mRNA, complete sequence.
AB384840 - Synthetic construct DNA, clone: pF1KB3702, Homo sapiens BMPR2 gene for bone morphogenetic protein receptor type-2 precursor, complete cds, without stop codon, in Flexi system.
LF317800 - JP 2014500723-A/125303: Polycomb-Associated Non-Coding RNAs.
MA553377 - JP 2018138019-A/125303: Polycomb-Associated Non-Coding RNAs.
BC018743 - Homo sapiens bone morphogenetic protein receptor, type II (serine/threonine kinase), mRNA (cDNA clone IMAGE:4876385), with apparent retained intron.
BC041039 - Homo sapiens bone morphogenetic protein receptor, type II (serine/threonine kinase), mRNA (cDNA clone IMAGE:4873415), with apparent retained intron.
JD484314 - Sequence 465338 from Patent EP1572962.
JD316742 - Sequence 297766 from Patent EP1572962.
LF317801 - JP 2014500723-A/125304: Polycomb-Associated Non-Coding RNAs.
MA553378 - JP 2018138019-A/125304: Polycomb-Associated Non-Coding RNAs.
JD358662 - Sequence 339686 from Patent EP1572962.
JD167717 - Sequence 148741 from Patent EP1572962.
LF317802 - JP 2014500723-A/125305: Polycomb-Associated Non-Coding RNAs.
MA553379 - JP 2018138019-A/125305: Polycomb-Associated Non-Coding RNAs.
JD516542 - Sequence 497566 from Patent EP1572962.
JD467623 - Sequence 448647 from Patent EP1572962.
JD326526 - Sequence 307550 from Patent EP1572962.
JD245265 - Sequence 226289 from Patent EP1572962.
JD358723 - Sequence 339747 from Patent EP1572962.
JD563976 - Sequence 545000 from Patent EP1572962.
JD192433 - Sequence 173457 from Patent EP1572962.
LF317803 - JP 2014500723-A/125306: Polycomb-Associated Non-Coding RNAs.
MA553380 - JP 2018138019-A/125306: Polycomb-Associated Non-Coding RNAs.
LF317806 - JP 2014500723-A/125309: Polycomb-Associated Non-Coding RNAs.
MA553383 - JP 2018138019-A/125309: Polycomb-Associated Non-Coding RNAs.
LF317807 - JP 2014500723-A/125310: Polycomb-Associated Non-Coding RNAs.
MA553384 - JP 2018138019-A/125310: Polycomb-Associated Non-Coding RNAs.
LF317808 - JP 2014500723-A/125311: Polycomb-Associated Non-Coding RNAs.
MA553385 - JP 2018138019-A/125311: Polycomb-Associated Non-Coding RNAs.
LF317810 - JP 2014500723-A/125313: Polycomb-Associated Non-Coding RNAs.
MA553387 - JP 2018138019-A/125313: Polycomb-Associated Non-Coding RNAs.
LF317811 - JP 2014500723-A/125314: Polycomb-Associated Non-Coding RNAs.
MA553388 - JP 2018138019-A/125314: Polycomb-Associated Non-Coding RNAs.
LF317812 - JP 2014500723-A/125315: Polycomb-Associated Non-Coding RNAs.
MA553389 - JP 2018138019-A/125315: Polycomb-Associated Non-Coding RNAs.
LF317813 - JP 2014500723-A/125316: Polycomb-Associated Non-Coding RNAs.
MA553390 - JP 2018138019-A/125316: Polycomb-Associated Non-Coding RNAs.
LF317814 - JP 2014500723-A/125317: Polycomb-Associated Non-Coding RNAs.
MA553391 - JP 2018138019-A/125317: Polycomb-Associated Non-Coding RNAs.
LF317815 - JP 2014500723-A/125318: Polycomb-Associated Non-Coding RNAs.
MA553392 - JP 2018138019-A/125318: Polycomb-Associated Non-Coding RNAs.
LF317817 - JP 2014500723-A/125320: Polycomb-Associated Non-Coding RNAs.
MA553394 - JP 2018138019-A/125320: Polycomb-Associated Non-Coding RNAs.
LF317819 - JP 2014500723-A/125322: Polycomb-Associated Non-Coding RNAs.
MA553396 - JP 2018138019-A/125322: Polycomb-Associated Non-Coding RNAs.
LF317820 - JP 2014500723-A/125323: Polycomb-Associated Non-Coding RNAs.
MA553397 - JP 2018138019-A/125323: Polycomb-Associated Non-Coding RNAs.
LF317821 - JP 2014500723-A/125324: Polycomb-Associated Non-Coding RNAs.
MA553398 - JP 2018138019-A/125324: Polycomb-Associated Non-Coding RNAs.
LF317822 - JP 2014500723-A/125325: Polycomb-Associated Non-Coding RNAs.
MA553399 - JP 2018138019-A/125325: Polycomb-Associated Non-Coding RNAs.
LF317823 - JP 2014500723-A/125326: Polycomb-Associated Non-Coding RNAs.
MA553400 - JP 2018138019-A/125326: Polycomb-Associated Non-Coding RNAs.
LF317824 - JP 2014500723-A/125327: Polycomb-Associated Non-Coding RNAs.
MA553401 - JP 2018138019-A/125327: Polycomb-Associated Non-Coding RNAs.
LF317825 - JP 2014500723-A/125328: Polycomb-Associated Non-Coding RNAs.
MA553402 - JP 2018138019-A/125328: Polycomb-Associated Non-Coding RNAs.
LF317826 - JP 2014500723-A/125329: Polycomb-Associated Non-Coding RNAs.
MA553403 - JP 2018138019-A/125329: Polycomb-Associated Non-Coding RNAs.
LF317827 - JP 2014500723-A/125330: Polycomb-Associated Non-Coding RNAs.
MA553404 - JP 2018138019-A/125330: Polycomb-Associated Non-Coding RNAs.
LF317828 - JP 2014500723-A/125331: Polycomb-Associated Non-Coding RNAs.
MA553405 - JP 2018138019-A/125331: Polycomb-Associated Non-Coding RNAs.
JD483475 - Sequence 464499 from Patent EP1572962.
JD113314 - Sequence 94338 from Patent EP1572962.
JD186028 - Sequence 167052 from Patent EP1572962.
JD241504 - Sequence 222528 from Patent EP1572962.
BC032011 - Homo sapiens bone morphogenetic protein receptor, type II (serine/threonine kinase), mRNA (cDNA clone IMAGE:3924242).
LF317829 - JP 2014500723-A/125332: Polycomb-Associated Non-Coding RNAs.
MA553406 - JP 2018138019-A/125332: Polycomb-Associated Non-Coding RNAs.
CQ873865 - Sequence 284 from Patent WO2004076622.
DD413702 - Regulation of Mammalian Cells.
LF317830 - JP 2014500723-A/125333: Polycomb-Associated Non-Coding RNAs.
MA553407 - JP 2018138019-A/125333: Polycomb-Associated Non-Coding RNAs.
AK023426 - Homo sapiens cDNA FLJ13364 fis, clone PLACE1000292.
LF317831 - JP 2014500723-A/125334: Polycomb-Associated Non-Coding RNAs.
MA553408 - JP 2018138019-A/125334: Polycomb-Associated Non-Coding RNAs.
JD430267 - Sequence 411291 from Patent EP1572962.
JD430269 - Sequence 411293 from Patent EP1572962.
JD430270 - Sequence 411294 from Patent EP1572962.
JD557435 - Sequence 538459 from Patent EP1572962.
JD557436 - Sequence 538460 from Patent EP1572962.
JD529331 - Sequence 510355 from Patent EP1572962.
JD529332 - Sequence 510356 from Patent EP1572962.
JD169524 - Sequence 150548 from Patent EP1572962.
JD169527 - Sequence 150551 from Patent EP1572962.
JD105000 - Sequence 86024 from Patent EP1572962.
AY277593 - Homo sapiens transformation-related protein 10 (TRG10) mRNA, complete cds.
BC043650 - Homo sapiens bone morphogenetic protein receptor, type II (serine/threonine kinase), mRNA (cDNA clone IMAGE:5277612).
LF317832 - JP 2014500723-A/125335: Polycomb-Associated Non-Coding RNAs.
MA553409 - JP 2018138019-A/125335: Polycomb-Associated Non-Coding RNAs.
LF317833 - JP 2014500723-A/125336: Polycomb-Associated Non-Coding RNAs.
MA553410 - JP 2018138019-A/125336: Polycomb-Associated Non-Coding RNAs.
AK123579 - Homo sapiens cDNA FLJ41585 fis, clone CTONG2020484.
JD496997 - Sequence 478021 from Patent EP1572962.
JD274898 - Sequence 255922 from Patent EP1572962.
JD274899 - Sequence 255923 from Patent EP1572962.
JD138274 - Sequence 119298 from Patent EP1572962.
JD175866 - Sequence 156890 from Patent EP1572962.
JD332286 - Sequence 313310 from Patent EP1572962.
JD517754 - Sequence 498778 from Patent EP1572962.
JD105973 - Sequence 86997 from Patent EP1572962.
BC035097 - Homo sapiens bone morphogenetic protein receptor, type II (serine/threonine kinase), mRNA (cDNA clone IMAGE:5261941).
LF317834 - JP 2014500723-A/125337: Polycomb-Associated Non-Coding RNAs.
MA553411 - JP 2018138019-A/125337: Polycomb-Associated Non-Coding RNAs.
AK093832 - Homo sapiens cDNA FLJ36513 fis, clone TRACH2001523.
LF317835 - JP 2014500723-A/125338: Polycomb-Associated Non-Coding RNAs.
MA553412 - JP 2018138019-A/125338: Polycomb-Associated Non-Coding RNAs.
LF317836 - JP 2014500723-A/125339: Polycomb-Associated Non-Coding RNAs.
MA553413 - JP 2018138019-A/125339: Polycomb-Associated Non-Coding RNAs.
LF317837 - JP 2014500723-A/125340: Polycomb-Associated Non-Coding RNAs.
MA553414 - JP 2018138019-A/125340: Polycomb-Associated Non-Coding RNAs.
LF317838 - JP 2014500723-A/125341: Polycomb-Associated Non-Coding RNAs.
MA553415 - JP 2018138019-A/125341: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04060 - Cytokine-cytokine receptor interaction
hsa04350 - TGF-beta signaling pathway

BioCarta from NCI Cancer Genome Anatomy Project
h_alkPathway - ALK in cardiac myocytes

Reactome (by CSHL, EBI, and GO)

Protein Q13873 (Reactome details) participates in the following event(s):

R-HSA-202604 Formation of a heteromeric BMP receptor complex
R-HSA-201475 I-Smad competes with R-Smad1/5/8 for type I receptor
R-HSA-201648 An anchoring protein, Endofin, recruits R-Smad1/5/8
R-HSA-201821 I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated
R-HSA-201443 Type II receptor phosphorylates type I receptor
R-HSA-201453 Phospho-R-Smad1/5/8 dissociates from the receptor complex
R-HSA-201476 Activated type I receptor phosphorylates R-Smad1/5/8 directly
R-HSA-201457 BMP2 binds to the receptor complex
R-HSA-201451 Signaling by BMP
R-HSA-9006936 Signaling by TGF-beta family members
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: BMPR2_HUMAN, ENST00000374580.1, ENST00000374580.2, ENST00000374580.3, ENST00000374580.4, ENST00000374580.5, ENST00000374580.6, ENST00000374580.7, ENST00000374580.8, ENST00000374580.9, NM_001204, PPH1, Q13873, Q16569, Q4ZG08, Q53SA5, Q585T8, uc002uzf.1, uc002uzf.2, uc002uzf.3, uc002uzf.4, uc002uzf.5, uc002uzf.6
UCSC ID: ENST00000374580.10
RefSeq Accession: NM_001204
Protein: Q13873 (aka BMPR2_HUMAN or BMR2_HUMAN)
CCDS: CCDS33361.1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene BMPR2:
pph (Heritable Pulmonary Arterial Hypertension Overview)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.