Human Gene ACSL3 (ENST00000357430.8) from GENCODE V44
Description: Homo sapiens acyl-CoA synthetase long chain family member 3 (ACSL3), transcript variant 2, mRNA. (from RefSeq NM_203372) RefSeq Summary (NM_004457): The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000357430.8 Gencode Gene: ENSG00000123983.15 Transcript (Including UTRs) Position: hg38 chr2:222,861,036-222,944,639 Size: 83,604 Total Exon Count: 17 Strand: + Coding Region Position: hg38 chr2:222,908,773-222,941,654 Size: 32,882 Coding Exon Count: 14
ID:ACSL3_HUMAN DESCRIPTION: RecName: Full=Long-chain-fatty-acid--CoA ligase 3; EC=6.2.1.3; AltName: Full=Long-chain acyl-CoA synthetase 3; Short=LACS 3; FUNCTION: Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins). CATALYTIC ACTIVITY: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. COFACTOR: Magnesium (By similarity). SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass type III membrane protein (By similarity). Peroxisome membrane; Single-pass type III membrane protein (By similarity). Microsome membrane; Single-pass type III membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type III membrane protein (By similarity). SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95573
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001676 long-chain fatty acid metabolic process GO:0006629 lipid metabolic process GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0007420 brain development GO:0007584 response to nutrient GO:0008152 metabolic process GO:0014070 response to organic cyclic compound GO:0034379 very-low-density lipoprotein particle assembly GO:0035338 long-chain fatty-acyl-CoA biosynthetic process GO:0042998 positive regulation of Golgi to plasma membrane protein transport GO:0044539 long-chain fatty acid import GO:0051047 positive regulation of secretion GO:2001247 positive regulation of phosphatidylcholine biosynthetic process