ID:CAB39_HUMAN DESCRIPTION: RecName: Full=Calcium-binding protein 39; AltName: Full=MO25alpha; AltName: Full=Protein Mo25; FUNCTION: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1. SUBUNIT: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. INTERACTION: Q15831:STK11; NbExp=4; IntAct=EBI-306905, EBI-306838; Q9C0K7:STRADB; NbExp=5; IntAct=EBI-306905, EBI-306893; SUBCELLULAR LOCATION: Cytoplasm (Potential). SIMILARITY: Belongs to the Mo25 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y376
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004674 protein serine/threonine kinase activity GO:0005515 protein binding GO:0019900 kinase binding GO:0030295 protein kinase activator activity GO:0043539 protein serine/threonine kinase activator activity
Biological Process: GO:0007050 cell cycle arrest GO:0010800 positive regulation of peptidyl-threonine phosphorylation GO:0018105 peptidyl-serine phosphorylation GO:0023014 signal transduction by protein phosphorylation GO:0032147 activation of protein kinase activity GO:0035556 intracellular signal transduction GO:0043312 neutrophil degranulation GO:0051291 protein heterooligomerization GO:0071476 cellular hypotonic response GO:0071902 positive regulation of protein serine/threonine kinase activity GO:1901017 negative regulation of potassium ion transmembrane transporter activity GO:1901380 negative regulation of potassium ion transmembrane transport
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