Human Gene ATP5PF (ENST00000400093.3) from GENCODE V44
Description: Homo sapiens ATP synthase peripheral stalk subunit F6 (ATP5PF), transcript variant 2, mRNA; nuclear gene for mitochondrial product. (from RefSeq NM_001685) RefSeq Summary (NM_001685): Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo complex has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the F6 subunit of the Fo complex. The F6 subunit is required for F1 and Fo interactions. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. This gene has 1 or more pseudogenes. [provided by RefSeq, Feb 2016]. Gencode Transcript: ENST00000400093.3 Gencode Gene: ENSG00000154723.13 Transcript (Including UTRs) Position: hg38 chr21:25,724,480-25,735,673 Size: 11,194 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr21:25,724,640-25,729,794 Size: 5,155 Coding Exon Count: 3
ID:Q6IB54_HUMAN DESCRIPTION: RecName: Full=ATP synthase-coupling factor 6, mitochondrial; Short=ATPase subunit F6; FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (By similarity). SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion inner membrane (By similarity). SIMILARITY: Belongs to the eukaryotic ATPase subunit F6 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05511 - Mitochondrial ATP synthase coupling factor 6
ModBase Predicted Comparative 3D Structure on Q6IB54
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
