Human Gene RBFOX2 (ENST00000405409.6) from GENCODE V44
Description: Homo sapiens RNA binding fox-1 homolog 2 (RBFOX2), transcript variant 2, mRNA. (from RefSeq NM_014309) RefSeq Summary (NM_014309): This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000405409.6 Gencode Gene: ENSG00000100320.24 Transcript (Including UTRs) Position: hg38 chr22:35,738,736-35,840,587 Size: 101,852 Total Exon Count: 12 Strand: - Coding Region Position: hg38 chr22:35,744,195-35,840,218 Size: 96,024 Coding Exon Count: 12
ID:RFOX2_HUMAN DESCRIPTION: RecName: Full=RNA binding protein fox-1 homolog 2; AltName: Full=Fox-1 homolog B; AltName: Full=Hexaribonucleotide-binding protein 2; AltName: Full=RNA-binding motif protein 9; AltName: Full=RNA-binding protein 9; AltName: Full=Repressor of tamoxifen transcriptional activity; FUNCTION: RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha. SUBUNIT: Interacts with ER-alpha N-terminal activation domain. INTERACTION: P54253:ATXN1; NbExp=6; IntAct=EBI-746056, EBI-930964; P03372:ESR1; NbExp=4; IntAct=EBI-746056, EBI-78473; Q96PU8:QKI; NbExp=2; IntAct=EBI-746056, EBI-945792; Q9NWB1:RBFOX1; NbExp=2; IntAct=EBI-746056, EBI-945906; SUBCELLULAR LOCATION: Nucleus. Cytoplasm (By similarity). SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43251
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.