Human Gene MCHR1 (ENST00000249016.5) from GENCODE V44
Description: Homo sapiens melanin concentrating hormone receptor 1 (MCHR1), mRNA. (from RefSeq NM_005297) RefSeq Summary (NM_005297): The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000249016.5 Gencode Gene: ENSG00000128285.5 Transcript (Including UTRs) Position: hg38 chr22:40,679,484-40,682,812 Size: 3,329 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr22:40,679,653-40,681,928 Size: 2,276 Coding Exon Count: 2
ID:MCHR1_HUMAN DESCRIPTION: RecName: Full=Melanin-concentrating hormone receptor 1; Short=MCH receptor 1; Short=MCH-R1; Short=MCHR-1; AltName: Full=G-protein coupled receptor 24; AltName: Full=MCH-1R; Short=MCH1R; Short=MCHR; AltName: Full=SLC-1; AltName: Full=Somatostatin receptor-like protein; FUNCTION: Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. SUBUNIT: Interacts with NCDN. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CAUTION: It is uncertain whether Met-1, Met-6 or Met-70 is the initiator. SEQUENCE CAUTION: Sequence=AAC14587.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99705
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
