Human Gene TGFBR2 (ENST00000295754.10) from GENCODE V43
  Description: Homo sapiens transforming growth factor beta receptor 2 (TGFBR2), transcript variant 2, mRNA. (from RefSeq NM_003242)
RefSeq Summary (NM_003242): The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017].
Gencode Transcript: ENST00000295754.10
Gencode Gene: ENSG00000163513.19
Transcript (Including UTRs)
   Position: hg38 chr3:30,606,601-30,694,142 Size: 87,542 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chr3:30,606,884-30,691,599 Size: 84,716 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesGeneReviewsMethods
Data last updated at UCSC: 2023-02-17 13:02:02

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr3:30,606,601-30,694,142)mRNA (may differ from genome)Protein (567 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=TGF-beta receptor type-2; Short=TGFR-2; EC=; AltName: Full=TGF-beta type II receptor; AltName: Full=Transforming growth factor-beta receptor type II; Short=TGF-beta receptor type II; Short=TbetaR-II; Flags: Precursor;
FUNCTION: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non- canonical, SMAD-independent TGF-beta signaling pathways.
CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor- protein] phosphate.
COFACTOR: Magnesium or manganese (By similarity).
SUBUNIT: Homodimer. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer. The respective affinity of TGFRB1 and TGFRB2 for the ligands may modulate the kinetics of assembly of the receptor and may explain the different biological activities of TGFB1, TGFB2 and TGFB3. Interacts with DAXX. Interacts with TCTEX1D4. Interacts with ZFYVE9; ZFYVE9 recruits SMAD2 and SMAD3 to the TGF- beta receptor. Interacts with and is activated by SCUBE3; this interaction does not affect TGFB1-binding to TGFBR2. Interacts with VPS39; this interaction is independent of the receptor kinase activity and of the presence of TGF-beta.
INTERACTION: Q9UER7:DAXX; NbExp=2; IntAct=EBI-296151, EBI-77321; Q8IX30:SCUBE3; NbExp=6; IntAct=EBI-296151, EBI-4479975; P01137:TGFB1; NbExp=4; IntAct=EBI-296151, EBI-779636; P07200:TGFB1 (xeno); NbExp=2; IntAct=EBI-296151, EBI-907660;
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
PTM: Phosphorylated on a Ser/Thr residue in the cytoplasmic domain.
DISEASE: Defects in TGFBR2 are the cause of hereditary non- polyposis colorectal cancer type 6 (HNPCC6) [MIM:614331]. Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world, and accounts for 15% of all colon cancers. Cancers in HNPCC originate within benign neoplastic polyps termed adenomas. Clinically, HNPCC is often divided into two subgroups. Type I: hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II: patients have an increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term "suspected HNPCC" or "incomplete HNPCC" can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected. HNPCC6 is a type of colorectal cancer complying with the clinical criteria of HNPCC, except that the onset of cancer was beyond 50 years of age in all cases.
DISEASE: Defects in TGFBR2 are a cause of esophageal cancer (ESCR) [MIM:133239].
DISEASE: Defects in TGFBR2 are the cause of Loeys-Dietz syndrome type 1B (LDS1B) [MIM:610168]. LDS1 is an aortic aneurysm syndrome with widespread systemic involvement. The disorder is characterized by arterial tortuosity and aneurysms, craniosynostosis, hypertelorism, and bifid uvula or cleft palate. Other findings include exotropy, micrognathia and retrognathia, structural brain abnormalities, intellectual deficit, congenital heart disease, translucent skin, joint hyperlaxity and aneurysm with dissection throughout the arterial tree.
DISEASE: Defects in TGFBR2 are the cause of Loeys-Dietz syndrome type 2B (LDS2B) [MIM:610380]. An aortic aneurysm syndrome with widespread systemic involvement. Physical findings include prominent joint laxity, easy bruising, wide and atrophic scars, velvety and translucent skin with easily visible veins, spontaneous rupture of the spleen or bowel, diffuse arterial aneurysms and dissections, and catastrophic complications of pregnancy, including rupture of the gravid uterus and the arteries, either during pregnancy or in the immediate postpartum period. LDS2 is characterized by the absence of craniofacial abnormalities with the exception of bifid uvula that can be present in some patients. Note=TGFBR2 mutations Cys-460 and His- 460 have been reported to be associated with thoracic aortic aneurysms and dissection (TAAD). This phenotype, also known as thoracic aortic aneurysms type 3 (AAT3), is distinguised from LDS2B by having aneurysms restricted to thoracic aorta. As individuals carrying these mutations also exhibit descending aortic disease and aneurysms of other arteries (PubMed:16027248), they have been considered as LDS2B by the OMIM resource.
SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
SIMILARITY: Contains 1 protein kinase domain.
WEB RESOURCE: Name=GeneReviews; URL="";

-  Primer design for this transcript

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-  MalaCards Disease Associations
  MalaCards Gene Search: TGFBR2
Diseases sorted by gene-association score: loeys-dietz syndrome 2* (1581), esophageal cancer* (1266), colorectal cancer, hereditary nonpolyposis, type 6* (1200), loeys-dietz syndrome* (551), thoracic aortic aneurysms and aortic dissections* (500), tgbfr2-related lynch syndrome* (500), tgfbr2-related loeys-dietz syndrome* (100), tgfbr2-related thoracic aortic aneurysms and aortic dissections* (100), aortic aneurysm (33), aneurysm (30), adenocarcinoma (29), marfan syndrome (25), aortic disease (24), intracranial hypotension (21), colorectal cancer 6 (20), familial thoracic aortic aneurysm and dissection (19), subclavian artery aneurysm (18), squamous cell carcinoma (15), colorectal cancer (13), aortic aneurysm, familial thoracic 1 (12), transient hypogammaglobulinemia of infancy (10), adenoma (10), multiple self-healing squamous epithelioma (8), craniosynostosis (8), autosomal dominant disease (8), transient hypogammaglobulinemia (8), tendinosis (8), diffuse gastric cancer (8), superficial urinary bladder cancer (7), patent ductus arteriosus (7), gastric cardia adenocarcinoma (7), bifid uvula (7), endometrial cancer (7), pancreatic cancer (6), hereditary hemorrhagic telangiectasia (6), ocular cicatricial pemphigoid (6), dental pulp calcification (6), eisenmenger syndrome (6), carotid artery dissection (5), char syndrome (4), gastric cancer, somatic (4), hepatocellular carcinoma (4), breast cancer (3), lung cancer (3), stomach cancer (2), cleft palate, isolated (2), pulmonary hypertension (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 135.43 RPKM in Adipose - Visceral (Omentum)
Total median expression: 2247.64 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -160.20283-0.566 Picture PostScript Text
3' UTR -691.402543-0.272 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000333 - Activin_II/TGFBeta-II_recpt
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR008271 - Ser/Thr_kinase_AS
IPR017194 - Transform_growth_fac-b_typ-2
IPR015013 - Transforming_GF_b_rcpt_2_ecto

Pfam Domains:
PF08917 - Transforming growth factor beta receptor 2 ectodomain
PF00069 - Protein kinase domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1KTZ - X-ray MuPIT 1M9Z - X-ray MuPIT 1PLO - NMR MuPIT 2PJY - X-ray MuPIT 3KFD - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on P37173
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005026 transforming growth factor beta receptor activity, type II
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005539 glycosaminoglycan binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0034713 type I transforming growth factor beta receptor binding
GO:0034714 type III transforming growth factor beta receptor binding
GO:0038023 signaling receptor activity
GO:0046332 SMAD binding
GO:0046872 metal ion binding
GO:0050431 transforming growth factor beta binding

Biological Process:
GO:0001568 blood vessel development
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001570 vasculogenesis
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001947 heart looping
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002088 lens development in camera-type eye
GO:0002651 positive regulation of tolerance induction to self antigen
GO:0002663 positive regulation of B cell tolerance induction
GO:0002666 positive regulation of T cell tolerance induction
GO:0003148 outflow tract septum morphogenesis
GO:0003149 membranous septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003181 atrioventricular valve morphogenesis
GO:0003186 tricuspid valve morphogenesis
GO:0003214 cardiac left ventricle morphogenesis
GO:0003274 endocardial cushion fusion
GO:0003417 growth plate cartilage development
GO:0003430 growth plate cartilage chondrocyte growth
GO:0006468 protein phosphorylation
GO:0006898 receptor-mediated endocytosis
GO:0006915 apoptotic process
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007182 common-partner SMAD protein phosphorylation
GO:0007219 Notch signaling pathway
GO:0007224 smoothened signaling pathway
GO:0007369 gastrulation
GO:0007420 brain development
GO:0007507 heart development
GO:0007566 embryo implantation
GO:0007568 aging
GO:0007584 response to nutrient
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009612 response to mechanical stimulus
GO:0009749 response to glucose
GO:0009887 animal organ morphogenesis
GO:0010033 response to organic substance
GO:0010468 regulation of gene expression
GO:0010634 positive regulation of epithelial cell migration
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0014070 response to organic cyclic compound
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030154 cell differentiation
GO:0030324 lung development
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031100 animal organ regeneration
GO:0032147 activation of protein kinase activity
GO:0035162 embryonic hemopoiesis
GO:0040008 regulation of growth
GO:0042060 wound healing
GO:0042127 regulation of cell proliferation
GO:0042493 response to drug
GO:0043011 myeloid dendritic cell differentiation
GO:0043415 positive regulation of skeletal muscle tissue regeneration
GO:0043627 response to estrogen
GO:0045766 positive regulation of angiogenesis
GO:0048545 response to steroid hormone
GO:0048565 digestive tract development
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0051138 positive regulation of NK T cell differentiation
GO:0051216 cartilage development
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060412 ventricular septum morphogenesis
GO:0060425 lung morphogenesis
GO:0060433 bronchus development
GO:0060434 bronchus morphogenesis
GO:0060439 trachea morphogenesis
GO:0060440 trachea formation
GO:0060443 mammary gland morphogenesis
GO:0060463 lung lobe morphogenesis
GO:0070723 response to cholesterol
GO:1905007 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO:1905317 inferior endocardial cushion morphogenesis
GO:1990086 lens fiber cell apoptotic process
GO:1990428 miRNA transport
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation
GO:1905315 cell proliferation involved in endocardial cushion morphogenesis
GO:1905316 superior endocardial cushion morphogenesis

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
GO:0045121 membrane raft
GO:0070022 transforming growth factor beta receptor complex

-  Descriptions from all associated GenBank mRNAs
  KJ901792 - Synthetic construct Homo sapiens clone ccsbBroadEn_11186 TGFBR2 gene, encodes complete protein.
KJ905329 - Synthetic construct Homo sapiens clone ccsbBroadEn_14862 TGFBR2 gene, encodes complete protein.
KR710922 - Synthetic construct Homo sapiens clone CCSBHm_00018177 TGFBR2 (TGFBR2) mRNA, encodes complete protein.
KR710923 - Synthetic construct Homo sapiens clone CCSBHm_00018180 TGFBR2 (TGFBR2) mRNA, encodes complete protein.
BC040499 - Homo sapiens transforming growth factor, beta receptor II (70/80kDa), mRNA (cDNA clone IMAGE:5287742).
LQ499612 - Sequence 3 from Patent WO2016075339.
MA129583 - JP 2018501816-A/3: Antisense-Oligonucleotides as Inhibitors of TGF-R signaling.
M85079 - Human TGF-beta type II receptor mRNA, complete cds.
AK314102 - Homo sapiens cDNA, FLJ94789, highly similar to Homo sapiens transforming growth factor, beta receptor II(70/80kDa) (TGFBR2), mRNA.
AK300383 - Homo sapiens cDNA FLJ53920 complete cds, highly similar to TGF-beta receptor type-2 precursor (EC
D50683 - Homo sapiens mRNA for TGF-betaIIR alpha, complete cds.
KC792576 - Homo sapiens transforming growth factor, beta receptor II alpha (TGFBR2) mRNA, complete cds, alternatively spliced.
KC792577 - Homo sapiens transforming growth factor, beta receptor II beta (TGFBR2) mRNA, complete cds, alternatively spliced.
KC792578 - Homo sapiens transforming growth factor, beta receptor II gamma (TGFBR2) mRNA, complete cds, alternatively spliced.
KC792579 - Homo sapiens transforming growth factor, beta receptor II delta (TGFBR2) mRNA, complete cds, alternatively spliced.
KC792580 - Homo sapiens transforming growth factor, beta receptor II epsilon (TGFBR2) mRNA, complete cds, alternatively spliced.
E10743 - cDNA encoding human transforming growth factor-beta(TGF-beta) receptor type II.
AB384947 - Synthetic construct DNA, clone: pF1KB4430, Homo sapiens TGFBR2 gene for TGF-beta receptor type-2 precursor, complete cds, without stop codon, in Flexi system.
BC152840 - Synthetic construct Homo sapiens clone IMAGE:100016037, MGC:184184 transforming growth factor, beta receptor II (70/80kDa) (TGFBR2) mRNA, encodes complete protein.
E10744 - cDNA encoding secretory signal and extracellular domain of human transforming growth factor-beta(TGF-beta) receptor type II.
KU178359 - Homo sapiens transforming growth factor beta receptor II isoform 1 (TGFBR2) mRNA, partial cds.
KU178360 - Homo sapiens transforming growth factor beta receptor II isoform 2 (TGFBR2) mRNA, partial cds.
D28131 - Homo sapiens mRNA for TGF-beta receptor type IIB, partial cds.
AK304404 - Homo sapiens cDNA FLJ51462 complete cds, highly similar to TGF-beta receptor type-2 precursor (EC
AJ786388 - Homo sapiens partial mRNA for transforming growth factor beta receptor type IIC, (Tbeta RIIC gene), alternative splicing.
MP202692 - Sequence 3 from Patent WO2019090263.
JD406172 - Sequence 387196 from Patent EP1572962.
JD395010 - Sequence 376034 from Patent EP1572962.
JD487648 - Sequence 468672 from Patent EP1572962.
JD220065 - Sequence 201089 from Patent EP1572962.
FW573294 - JP 2010529847-A/15: Oligonucleotides for modulation of target RNA activity.
JD119569 - Sequence 100593 from Patent EP1572962.
JD553849 - Sequence 534873 from Patent EP1572962.
JD279910 - Sequence 260934 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway
hsa04060 - Cytokine-cytokine receptor interaction
hsa04144 - Endocytosis
hsa04350 - TGF-beta signaling pathway
hsa04520 - Adherens junction
hsa05142 - Chagas disease
hsa05200 - Pathways in cancer
hsa05210 - Colorectal cancer
hsa05212 - Pancreatic cancer
hsa05220 - Chronic myeloid leukemia

BioCarta from NCI Cancer Genome Anatomy Project
h_tgfbPathway - TGF beta signaling pathway
h_nthiPathway - NFkB activation by Nontypeable Hemophilus influenzae
h_alkPathway - ALK in cardiac myocytes
h_ctcfPathway - CTCF: First Multivalent Nuclear Factor
h_tob1Pathway - Role of Tob in T-cell activation

Reactome (by CSHL, EBI, and GO)

Protein P37173 (Reactome details) participates in the following event(s):

R-HSA-170861 Dimeric TGF-beta-1 binds to the receptor
R-HSA-4332235 CBL binds TGFBR2
R-HSA-4332236 CBL neddylates TGFBR2
R-HSA-3645778 TGFB1 binds TGFBR2 KD Mutant Dimers
R-HSA-170843 TGFBR2 phosphorylates TGFBR1
R-HSA-170846 TGFBR2 recruits TGFBR1
R-HSA-170835 An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
R-HSA-173483 BAMBI interferes with the interaction of type I receptor with type II receptor
R-HSA-173512 I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
R-HSA-178218 SMAD7:SMURF complex binds to phosphorylated TGFBR1
R-HSA-2127562 STRAP binds phosphorylated TGF-beta receptor complex
R-NUL-2128982 Strap binds phosphorylated TGF-beta receptor complex
R-NUL-2169036 Smad7:SMURF1 binds phosphorylated TGFBR1
R-NUL-2169043 Smad7:SMURF2 binds phosphorylated TGFBR1
R-NUL-2176431 Smad7 recruits NEDD4L to activated TGF-beta receptor complex
R-HSA-3702153 An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 MH2 domain mutants
R-HSA-3713560 An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 phosphorylation motif mutants
R-HSA-2134519 TGFBR2 is recruited to tight junctions after TGF-beta stimulation
R-NUL-2161160 TGFBR2 is recruited to tight junctions-associated, Pard6a-bound, TGFBR1 after TGF-beta stimulation
R-HSA-3656484 TGFBR2 recruits TGFBR1 KD Mutants
R-HSA-170850 Phosphorylated SMAD2/3 dissociates from TGFBR
R-HSA-3702186 Phosphorylated SMAD2/3 MH2 domain mutants dissociate from TGFBR
R-HSA-170868 Activated type I receptor phosphorylates SMAD2/3 directly
R-HSA-178178 PP1 dephosphorylates TGFBR1
R-NUL-2167872 PP1CC dephosphorylates TGFBR1
R-NUL-2167890 Smad7 recruits GADD34:PP1CC to phosphorylated TGF-beta receptor complex
R-HSA-3656517 TGFBR2 phosphorylates TGFBR1 KD Mutants
R-HSA-3702184 Activated type I receptor phosphorylates SMAD2/3 MH2 domain mutants directly
R-HSA-2134532 TGFBR2 phosphorylates TGFBR1 and PARD6A
R-NUL-2161165 TGFBR2 phosphorylates Pard6a
R-HSA-178189 SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
R-HSA-2128994 STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
R-HSA-2160932 SMURF1 binds phosphorylated PARD6A
R-HSA-2169050 SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
R-NUL-2176396 SMURF1 ubiquitinates Smad7 and phosphorylated TGFBR1
R-NUL-2176393 SMURF2 ubiquitinates Smad7 and phosphorylated TGFBR1
R-NUL-2176427 NEDD4L ubiquitinates Smad7 and TGFBR1
R-NUL-2179307 Uchl5 is recruited to TGF-beta receptor complex through Smad7
R-NUL-2179313 Uchl5 deubiquitinates TGFBR1
R-HSA-3645786 TGFBR2 mutant dimers recruit TGFBR1
R-HSA-2179293 UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
R-HSA-2179291 UCHL5, USP15 deubiquitinate TGFBR1
R-HSA-2160935 SMURF1 ubiquitinates RHOA
R-HSA-2173789 TGF-beta receptor signaling activates SMADs
R-HSA-170834 Signaling by TGF-beta Receptor Complex
R-HSA-3645790 TGFBR2 Kinase Domain Mutants in Cancer
R-HSA-3642279 TGFBR2 MSI Frameshift Mutants in Cancer
R-HSA-2173788 Downregulation of TGF-beta receptor signaling
R-HSA-3315487 SMAD2/3 MH2 Domain Mutants in Cancer
R-HSA-3304356 SMAD2/3 Phosphorylation Motif Mutants in Cancer
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-3656535 TGFBR1 LBD Mutants in Cancer
R-HSA-3656532 TGFBR1 KD Mutants in Cancer
R-HSA-9006936 Signaling by TGF-beta family members
R-HSA-3642278 Loss of Function of TGFBR2 in Cancer
R-HSA-3304349 Loss of Function of SMAD2/3 in Cancer
R-HSA-3656534 Loss of Function of TGFBR1 in Cancer
R-HSA-162582 Signal Transduction
R-HSA-3304351 Signaling by TGF-beta Receptor Complex in Cancer
R-HSA-5689603 UCH proteinases
R-HSA-5663202 Diseases of signal transduction
R-HSA-5688426 Deubiquitination
R-HSA-1643685 Disease
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: B4DTV5, ENST00000295754.1, ENST00000295754.2, ENST00000295754.3, ENST00000295754.4, ENST00000295754.5, ENST00000295754.6, ENST00000295754.7, ENST00000295754.8, ENST00000295754.9, NM_003242, P37173, Q15580, Q6DKT6, Q99474, TGFR2_HUMAN, uc003ceo.1, uc003ceo.2, uc003ceo.3, uc003ceo.4, uc003ceo.5
UCSC ID: ENST00000295754.10
RefSeq Accession: NM_003242
Protein: P37173 (aka TGFR2_HUMAN or TGR2_HUMAN)
CCDS: CCDS2648.1, CCDS33727.1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene TGFBR2:
loeys-dietz (Loeys-Dietz Syndrome)
taa (Heritable Thoracic Aortic Disease Overview)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.