Human Gene CAMKV (ENST00000477224.6) from GENCODE V44
  Description: Homo sapiens CaM kinase like vesicle associated (CAMKV), transcript variant 1, mRNA. (from RefSeq NM_024046)
Gencode Transcript: ENST00000477224.6
Gencode Gene: ENSG00000164076.17
Transcript (Including UTRs)
   Position: hg38 chr3:49,857,989-49,869,906 Size: 11,918 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg38 chr3:49,859,318-49,862,388 Size: 3,071 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:49,857,989-49,869,906)mRNA (may differ from genome)Protein (501 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CAMKV_HUMAN
DESCRIPTION: RecName: Full=CaM kinase-like vesicle-associated protein;
FUNCTION: Does not appear to have detectable kinase activity.
COFACTOR: Calcium (By similarity).
SUBUNIT: Interacts with calmodulin, in the presence of calcium (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein (By similarity). Cytoplasmic vesicle membrane; Peripheral membrane protein (By similarity). Note=Predominantly observed in association with the plasma membrane of soma and in neurites, both axons and dendrites. May be associated with vesicular structures (By similarity).
DOMAIN: The protein kinase domain is predicted to be catalytically inactive.
SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
SIMILARITY: Contains 1 protein kinase domain.

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 147.84 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 648.12 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -63.80163-0.391 Picture PostScript Text
3' UTR -551.101329-0.415 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020636 - Ca/CaM-dep_Ca-dep_prot_Kinase
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR002290 - Ser/Thr_dual-sp_kinase_dom

Pfam Domains:
PF00069 - Protein kinase domain

ModBase Predicted Comparative 3D Structure on Q8NCB2
FrontTopSide
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004672 protein kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding

Biological Process:
GO:0006468 protein phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0035556 intracellular signal transduction

Cellular Component:
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle


-  Descriptions from all associated GenBank mRNAs
  LF208621 - JP 2014500723-A/16124: Polycomb-Associated Non-Coding RNAs.
MA444198 - JP 2018138019-A/16124: Polycomb-Associated Non-Coding RNAs.
AL833943 - Homo sapiens mRNA; cDNA DKFZp564G2082 (from clone DKFZp564G2082).
BX647074 - Homo sapiens mRNA; cDNA DKFZp686D0882 (from clone DKFZp686D0882).
BC019256 - Homo sapiens CaM kinase-like vesicle-associated, mRNA (cDNA clone MGC:1821 IMAGE:3502894), complete cds.
BC000497 - Homo sapiens CaM kinase-like vesicle-associated, mRNA (cDNA clone MGC:8407 IMAGE:2820734), complete cds.
BC001921 - Homo sapiens CaM kinase-like vesicle-associated, mRNA (cDNA clone MGC:3732 IMAGE:2820734), complete cds.
BC005828 - Homo sapiens CaM kinase-like vesicle-associated, mRNA (cDNA clone MGC:1820 IMAGE:2820734), complete cds.
BC017363 - Homo sapiens CaM kinase-like vesicle-associated, mRNA (cDNA clone MGC:10408 IMAGE:3940018), complete cds.
AL136697 - Homo sapiens mRNA; cDNA DKFZp564E0482 (from clone DKFZp564E0482).
AK074899 - Homo sapiens cDNA FLJ90418 fis, clone NT2RP3000172, weakly similar to CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE I (EC 2.7.1.123).
AK075294 - Homo sapiens cDNA FLJ90813 fis, clone Y79AA1000967, weakly similar to CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE I (EC 2.7.1.123).
BC033374 - Homo sapiens CaM kinase-like vesicle-associated, mRNA (cDNA clone IMAGE:4934142).
AL834461 - Homo sapiens mRNA; cDNA DKFZp566K241 (from clone DKFZp566K241).
JD025981 - Sequence 7005 from Patent EP1572962.
AK074856 - Homo sapiens cDNA FLJ90375 fis, clone NT2RP2004670, highly similar to Rattus norvegicus vesicla-associate calmodulin-binding protein mRNA.
JD423808 - Sequence 404832 from Patent EP1572962.
JD030761 - Sequence 11785 from Patent EP1572962.
JD227197 - Sequence 208221 from Patent EP1572962.
JD545926 - Sequence 526950 from Patent EP1572962.
JD279212 - Sequence 260236 from Patent EP1572962.
JD084513 - Sequence 65537 from Patent EP1572962.
JD305129 - Sequence 286153 from Patent EP1572962.
JD039454 - Sequence 20478 from Patent EP1572962.
JD290828 - Sequence 271852 from Patent EP1572962.
JD166350 - Sequence 147374 from Patent EP1572962.
JD130220 - Sequence 111244 from Patent EP1572962.
JD218226 - Sequence 199250 from Patent EP1572962.
JD303569 - Sequence 284593 from Patent EP1572962.
JD071316 - Sequence 52340 from Patent EP1572962.
JD321677 - Sequence 302701 from Patent EP1572962.
JD340590 - Sequence 321614 from Patent EP1572962.
JD282642 - Sequence 263666 from Patent EP1572962.
LF378468 - JP 2014500723-A/185971: Polycomb-Associated Non-Coding RNAs.
MA614045 - JP 2018138019-A/185971: Polycomb-Associated Non-Coding RNAs.
JD079351 - Sequence 60375 from Patent EP1572962.
JD186506 - Sequence 167530 from Patent EP1572962.
JD200676 - Sequence 181700 from Patent EP1572962.
JD192636 - Sequence 173660 from Patent EP1572962.
JD365207 - Sequence 346231 from Patent EP1572962.
JD519273 - Sequence 500297 from Patent EP1572962.
JD253500 - Sequence 234524 from Patent EP1572962.
JD556765 - Sequence 537789 from Patent EP1572962.
JD429945 - Sequence 410969 from Patent EP1572962.
JD402868 - Sequence 383892 from Patent EP1572962.
JD394159 - Sequence 375183 from Patent EP1572962.
JD242107 - Sequence 223131 from Patent EP1572962.
JD272621 - Sequence 253645 from Patent EP1572962.
JD235771 - Sequence 216795 from Patent EP1572962.
JD335937 - Sequence 316961 from Patent EP1572962.
JD453006 - Sequence 434030 from Patent EP1572962.
JD347330 - Sequence 328354 from Patent EP1572962.
JD266904 - Sequence 247928 from Patent EP1572962.
AK226073 - Homo sapiens mRNA for CaM kinase-like vesicle-associated variant, clone: fk15481.
CR533508 - Homo sapiens full open reading frame cDNA clone RZPDo834D0819D for gene MGC8407, hypothetical protein MGC8407; complete cds, incl. stopcodon.
AK297437 - Homo sapiens cDNA FLJ54087 complete cds, highly similar to Homo sapiens CaM kinase-like vesicle-associated (CAMKV), mRNA.
AK297258 - Homo sapiens cDNA FLJ54113 complete cds, highly similar to Homo sapiens CaM kinase-like vesicle-associated (CAMKV), mRNA.
AK295588 - Homo sapiens cDNA FLJ59535 complete cds, highly similar to Homo sapiens CaM kinase-like vesicle-associated (CAMKV), mRNA.
JD179445 - Sequence 160469 from Patent EP1572962.
JD178424 - Sequence 159448 from Patent EP1572962.
JD361065 - Sequence 342089 from Patent EP1572962.
HM005675 - Homo sapiens clone HTL-T-52e testis tissue sperm-binding protein Li 52e mRNA, complete cds.
AK315525 - Homo sapiens cDNA, FLJ96591.
KJ899511 - Synthetic construct Homo sapiens clone ccsbBroadEn_08905 CAMKV gene, encodes complete protein.
KJ905532 - Synthetic construct Homo sapiens clone ccsbBroadEn_15144 CAMKV gene, encodes complete protein.
KJ906306 - Synthetic construct Homo sapiens clone ccsbBroadEn_15976 CAMKV gene, encodes complete protein.
DQ891404 - Synthetic construct clone IMAGE:100004034; FLH176617.01X; RZPDo839F05122D CaM kinase-like vesicle-associated (CAMKV) gene, encodes complete protein.
DQ896819 - Synthetic construct Homo sapiens clone IMAGE:100011279; FLH176613.01L; RZPDo839F05121D CaM kinase-like vesicle-associated (CAMKV) gene, encodes complete protein.
LF378467 - JP 2014500723-A/185970: Polycomb-Associated Non-Coding RNAs.
MA614044 - JP 2018138019-A/185970: Polycomb-Associated Non-Coding RNAs.
LF378466 - JP 2014500723-A/185969: Polycomb-Associated Non-Coding RNAs.
MA614043 - JP 2018138019-A/185969: Polycomb-Associated Non-Coding RNAs.
AK299953 - Homo sapiens cDNA FLJ53649 complete cds, highly similar to Mus musculus CaM kinase-like vesicle-associated (Camkv), mRNA.
LF378465 - JP 2014500723-A/185968: Polycomb-Associated Non-Coding RNAs.
MA614042 - JP 2018138019-A/185968: Polycomb-Associated Non-Coding RNAs.
LF378464 - JP 2014500723-A/185967: Polycomb-Associated Non-Coding RNAs.
MA614041 - JP 2018138019-A/185967: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NFD4, CAMKV_HUMAN, ENST00000477224.1, ENST00000477224.2, ENST00000477224.3, ENST00000477224.4, ENST00000477224.5, NM_024046, Q6FIB8, Q8NBS8, Q8NC85, Q8NCB2, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5, uc003cxt.1, uc003cxt.2, uc003cxt.3
UCSC ID: ENST00000477224.6
RefSeq Accession: NM_024046
Protein: Q8NCB2 (aka CAMKV_HUMAN)
CCDS: CCDS33762.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.