Human Gene NEK4 (ENST00000233027.10) from GENCODE V44
Description: Homo sapiens NIMA related kinase 4 (NEK4), transcript variant 1, mRNA. (from RefSeq NM_003157) RefSeq Summary (NM_003157): The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017]. Gencode Transcript: ENST00000233027.10 Gencode Gene: ENSG00000114904.13 Transcript (Including UTRs) Position: hg38 chr3:52,708,444-52,770,940 Size: 62,497 Total Exon Count: 16 Strand: - Coding Region Position: hg38 chr3:52,711,777-52,770,746 Size: 58,970 Coding Exon Count: 16
ID:NEK4_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein kinase Nek4; EC=2.7.11.1; AltName: Full=Never in mitosis A-related kinase 4; Short=NimA-related protein kinase 4; AltName: Full=Serine/threonine-protein kinase 2; AltName: Full=Serine/threonine-protein kinase NRK2; FUNCTION: Seems to act exclusively upon threonine residues (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium (By similarity). SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Highest expression in adult heart, followed by pancreas, skeletal muscle, brain, liver, kidney, lung and placenta. Present in most primary carcinomas. SIMILARITY: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P51957
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000278 mitotic cell cycle GO:0006468 protein phosphorylation GO:0006974 cellular response to DNA damage stimulus GO:0007049 cell cycle GO:0007346 regulation of mitotic cell cycle GO:0016310 phosphorylation GO:0023014 signal transduction by protein phosphorylation GO:0031098 stress-activated protein kinase signaling cascade GO:0032147 activation of protein kinase activity GO:0042981 regulation of apoptotic process GO:0045893 positive regulation of transcription, DNA-templated GO:0051301 cell division GO:1900062 regulation of replicative cell aging GO:2000772 regulation of cellular senescence GO:2001020 regulation of response to DNA damage stimulus