Human Gene IGF2BP2 (ENST00000382199.7) from GENCODE V44
Description: Homo sapiens insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2), transcript variant 1, mRNA. (from RefSeq NM_006548) RefSeq Summary (NM_006548): This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]. Gencode Transcript: ENST00000382199.7 Gencode Gene: ENSG00000073792.16 Transcript (Including UTRs) Position: hg38 chr3:185,643,130-185,825,042 Size: 181,913 Total Exon Count: 16 Strand: - Coding Region Position: hg38 chr3:185,645,531-185,824,960 Size: 179,430 Coding Exon Count: 16
ID:IF2B2_HUMAN DESCRIPTION: RecName: Full=Insulin-like growth factor 2 mRNA-binding protein 2; Short=IGF2 mRNA-binding protein 2; Short=IMP-2; AltName: Full=Hepatocellular carcinoma autoantigen p62; AltName: Full=IGF-II mRNA-binding protein 2; AltName: Full=VICKZ family member 2; FUNCTION: Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. May regulate translation of target mRNAs. SUBUNIT: Interacts with HNRPD and IGF2BP1. INTERACTION: Q14103-4:HNRNPD; NbExp=4; IntAct=EBI-1024419, EBI-432545; SUBCELLULAR LOCATION: Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. TISSUE SPECIFICITY: Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis. DOMAIN: The third and fourth KH domains are important for binding to the untranslated region (UTR) of target mRNA. MISCELLANEOUS: Autoantibodies against IGF2BP2 are detected in sera from some patients with hepatocellular carcinoma. SIMILARITY: Belongs to the RRM IMP/VICKZ family. SIMILARITY: Contains 4 KH domains. SIMILARITY: Contains 2 RRM (RNA recognition motif) domains. SEQUENCE CAUTION: Sequence=AAH21290.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y6M1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006417 regulation of translation GO:0009653 anatomical structure morphogenesis GO:0017148 negative regulation of translation GO:0042035 regulation of cytokine biosynthetic process GO:0043488 regulation of mRNA stability GO:0051028 mRNA transport
US Server
