Human Gene PRKG2 (ENST00000264399.6) from GENCODE V44
Description: Homo sapiens protein kinase cGMP-dependent 2 (PRKG2), transcript variant 1, mRNA. (from RefSeq NM_006259) RefSeq Summary (NM_001363401): This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein binds to and inhibits the activation of several receptor tyrosine kinases. The membrane-bound protein is a regulator of intestinal secretion, bone growth and renin secretion. Alternate splicing results in multiple transcript variants encoding distinct isoforms whose regulatory N-termini differ in length but whose C-terminal catalytic domains are identical. [provided by RefSeq, May 2018]. Gencode Transcript: ENST00000264399.6 Gencode Gene: ENSG00000138669.10 Transcript (Including UTRs) Position: hg38 chr4:81,087,375-81,215,222 Size: 127,848 Total Exon Count: 19 Strand: - Coding Region Position: hg38 chr4:81,089,708-81,205,047 Size: 115,340 Coding Exon Count: 18
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13237
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006468 protein phosphorylation GO:0007165 signal transduction GO:0016310 phosphorylation GO:0036289 peptidyl-serine autophosphorylation GO:0051186 cofactor metabolic process GO:0072659 protein localization to plasma membrane GO:2001226 negative regulation of chloride transport
X94612 - H.sapiens mRNA for type II cGMP-dependent protein kinase. AK297673 - Homo sapiens cDNA FLJ56575 complete cds, highly similar to cGMP-dependent protein kinase 2 (EC 2.7.11.12). AK316140 - Homo sapiens cDNA, FLJ79039 complete cds, highly similar to cGMP-dependent protein kinase 2 (EC 2.7.11.12). AK296979 - Homo sapiens cDNA FLJ56988 complete cds, highly similar to cGMP-dependent protein kinase 2 (EC 2.7.11.12). HM005412 - Homo sapiens clone HTL-T-99 testicular tissue protein Li 99 mRNA, complete cds. BC111597 - Synthetic construct Homo sapiens clone IMAGE:40080555, MGC:133418 PRKG2 protein (PRKG2) mRNA, encodes complete protein. D70899 - Homo sapiens mRNA for cGMP-dependent protein kinase II, complete cds. AB528214 - Synthetic construct DNA, clone: pF1KB5772, Homo sapiens PRKG2 gene for protein kinase, cGMP-dependent, type II, without stop codon, in Flexi system. JD265333 - Sequence 246357 from Patent EP1572962. JD303147 - Sequence 284171 from Patent EP1572962. JD166564 - Sequence 147588 from Patent EP1572962. JD079239 - Sequence 60263 from Patent EP1572962. JD180570 - Sequence 161594 from Patent EP1572962. JD406369 - Sequence 387393 from Patent EP1572962. JD067201 - Sequence 48225 from Patent EP1572962. JD260613 - Sequence 241637 from Patent EP1572962. JD251202 - Sequence 232226 from Patent EP1572962. JD276785 - Sequence 257809 from Patent EP1572962. JD510165 - Sequence 491189 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q13237 (Reactome details) participates in the following event(s):
R-HSA-418451 cGMP stimulates Protein Kinase G R-HSA-1475422 PTPS is phosphorylated by cGMP-dependant protein kinase II R-HSA-1497853 Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II R-HSA-4551453 PRKG is activated by binding to high levels of cGMP in the absence of WNT signaling R-HSA-418442 PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release R-HSA-418549 PKG1 phosphorylates BK channels R-HSA-418457 cGMP effects R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-4086398 Ca2+ pathway R-HSA-392154 Nitric oxide stimulates guanylate cyclase R-HSA-8978934 Metabolism of cofactors R-HSA-3858494 Beta-catenin independent WNT signaling R-HSA-418346 Platelet homeostasis R-HSA-196854 Metabolism of vitamins and cofactors R-HSA-195721 Signaling by WNT R-HSA-109582 Hemostasis R-HSA-1430728 Metabolism R-HSA-162582 Signal Transduction
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