Human Gene GYPB (ENST00000502664.6) from GENCODE V44
Description: Homo sapiens glycophorin B (MNS blood group) (GYPB), transcript variant 1, mRNA. (from RefSeq NM_002100) RefSeq Summary (NM_002100): Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]. Gencode Transcript: ENST00000502664.6 Gencode Gene: ENSG00000250361.10 Transcript (Including UTRs) Position: hg38 chr4:143,996,104-144,019,380 Size: 23,277 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr4:143,996,299-144,019,287 Size: 22,989 Coding Exon Count: 5
ID:GLPB_HUMAN DESCRIPTION: RecName: Full=Glycophorin-B; AltName: Full=PAS-3; AltName: Full=SS-active sialoglycoprotein; AltName: Full=Sialoglycoprotein delta; AltName: CD_antigen=CD235b; Flags: Precursor; FUNCTION: This protein is a minor sialoglycoprotein in erythrocyte membranes. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. PTM: The N-terminal extracellular domain is heavily glycosylated on serine and threonine residues. POLYMORPHISM: Along with GYPA, GYPB is responsible for the MNS blood group system. The molecular basis of the S/s blood group antigen is a single variation in position 48; Thr-48 corresponds to s=MSN4 and Met-48 to S=MNS3. SIMILARITY: Belongs to the glycophorin-A family. WEB RESOURCE: Name=dbRBC/BGMUT; Note=Blood group antigen gene mutation database; URL="http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=mns";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P06028
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary