Human Gene HMGB2 (ENST00000296503.10) from GENCODE V44
Description: Homo sapiens high mobility group box 2 (HMGB2), transcript variant 1, mRNA. (from RefSeq NM_002129) RefSeq Summary (NM_002129): This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000296503.10 Gencode Gene: ENSG00000164104.12 Transcript (Including UTRs) Position: hg38 chr4:173,331,376-173,334,358 Size: 2,983 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr4:173,332,080-173,333,649 Size: 1,570 Coding Exon Count: 4
ID:HMGB2_HUMAN DESCRIPTION: RecName: Full=High mobility group protein B2; AltName: Full=High mobility group protein 2; Short=HMG-2; FUNCTION: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). SUBUNIT: Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2 (By similarity). Component of the SET complex, which also contains SET, ANP32A, APEX1 and NME1. Directly interacts with SET. SUBCELLULAR LOCATION: Nucleus. Chromosome. SIMILARITY: Belongs to the HMGB family. SIMILARITY: Contains 2 HMG box DNA-binding domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P26583
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001938 positive regulation of endothelial cell proliferation GO:0002376 immune system process GO:0002437 inflammatory response to antigenic stimulus GO:0006265 DNA topological change GO:0006309 apoptotic DNA fragmentation GO:0006310 DNA recombination GO:0006325 chromatin organization GO:0006334 nucleosome assembly GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006935 chemotaxis GO:0006954 inflammatory response GO:0007283 spermatogenesis GO:0007289 spermatid nucleus differentiation GO:0008584 male gonad development GO:0010628 positive regulation of gene expression GO:0010629 negative regulation of gene expression GO:0032075 positive regulation of nuclease activity GO:0032392 DNA geometric change GO:0032496 response to lipopolysaccharide GO:0032728 positive regulation of interferon-beta production GO:0033151 V(D)J recombination GO:0042493 response to drug GO:0043388 positive regulation of DNA binding GO:0045087 innate immune response GO:0045089 positive regulation of innate immune response GO:0045648 positive regulation of erythrocyte differentiation GO:0045654 positive regulation of megakaryocyte differentiation GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048545 response to steroid hormone GO:0050767 regulation of neurogenesis GO:0050829 defense response to Gram-negative bacterium GO:0050830 defense response to Gram-positive bacterium GO:0050918 positive chemotaxis GO:0051103 DNA ligation involved in DNA repair GO:0060326 cell chemotaxis GO:0071222 cellular response to lipopolysaccharide GO:0072091 regulation of stem cell proliferation GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
BioCarta from NCI Cancer Genome Anatomy Project h_DNAfragmentPathway - Apoptotic DNA fragmentation and tissue homeostasis h_setPathway - Granzyme A mediated Apoptosis Pathway
Reactome (by CSHL, EBI, and GO)
Protein P26583 (Reactome details) participates in the following event(s):
US Server
