Human Gene CENPH (ENST00000283006.7) from GENCODE V44
Description: Homo sapiens centromere protein H (CENPH), mRNA. (from RefSeq NM_022909) RefSeq Summary (NM_022909): Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000283006.7 Gencode Gene: ENSG00000153044.10 Transcript (Including UTRs) Position: hg38 chr5:69,189,583-69,210,357 Size: 20,775 Total Exon Count: 9 Strand: + Coding Region Position: hg38 chr5:69,189,635-69,209,799 Size: 20,165 Coding Exon Count: 9
ID:CENPH_HUMAN DESCRIPTION: RecName: Full=Centromere protein H; Short=CENP-H; AltName: Full=Interphase centromere complex protein 35; FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. SUBUNIT: Self-associates. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Interacts directly with CENPK. Interacts with KIF2C and NDC80. Interacts with TRIM36 (By similarity). INTERACTION: O14777:NDC80; NbExp=3; IntAct=EBI-1003700, EBI-715849; SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore. Note=Associates with active centromere-kinetochore complexes throughout the cell cycle. Colocalizes with inner kinetochore plate proteins CENPA and CENPC1 during both interphase and metaphase. SIMILARITY: Belongs to the centromere protein H family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05837 - Centromere protein H (CENP-H)
ModBase Predicted Comparative 3D Structure on Q9H3R5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK290746 - Homo sapiens cDNA FLJ76140 complete cds, highly similar to Homo sapiens centromere protein H (CENPH), mRNA. BC015355 - Homo sapiens centromere protein H, mRNA (cDNA clone MGC:21458 IMAGE:3451767), complete cds. BC012024 - Homo sapiens centromere protein H, mRNA (cDNA clone MGC:21431 IMAGE:4510607), complete cds. AK123761 - Homo sapiens cDNA FLJ41767 fis, clone IMR322006495, highly similar to Centromere protein H (Kinetochore protein CENP-H). KU178758 - Homo sapiens centromere protein H isoform 1 (CENPH) mRNA, partial cds. KU178759 - Homo sapiens centromere protein H isoform 2 (CENPH) mRNA, complete cds, alternatively spliced. DQ894658 - Synthetic construct Homo sapiens clone IMAGE:100009118; FLH177277.01L; RZPDo839F08123D centromere protein H (CENPH) gene, encodes complete protein. AB035124 - Homo sapiens mRNA for kinetochore protein CENP-H, complete cds. KJ894593 - Synthetic construct Homo sapiens clone ccsbBroadEn_03987 CENPH gene, encodes complete protein. CU680168 - Synthetic construct Homo sapiens gateway clone IMAGE:100016885 5' read CENPH mRNA. JD040889 - Sequence 21913 from Patent EP1572962. DQ587113 - Homo sapiens piRNA piR-54225, complete sequence. JD385540 - Sequence 366564 from Patent EP1572962. JD564604 - Sequence 545628 from Patent EP1572962. JD564603 - Sequence 545627 from Patent EP1572962. JD531657 - Sequence 512681 from Patent EP1572962. JD396176 - Sequence 377200 from Patent EP1572962. JD409266 - Sequence 390290 from Patent EP1572962. JD489082 - Sequence 470106 from Patent EP1572962. JD309789 - Sequence 290813 from Patent EP1572962. JD070002 - Sequence 51026 from Patent EP1572962. JD502842 - Sequence 483866 from Patent EP1572962. JD479922 - Sequence 460946 from Patent EP1572962. JD200677 - Sequence 181701 from Patent EP1572962. JD476477 - Sequence 457501 from Patent EP1572962. JD411595 - Sequence 392619 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9H3R5 (Reactome details) participates in the following event(s):
R-HSA-606349 Mis18 complex binds the centromere R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-606326 HJURP:CENPA complex localizes to the centromere R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-774815 Nucleosome assembly R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-73886 Chromosome Maintenance R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-1640170 Cell Cycle R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-162582 Signal Transduction
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