ID:HPLN1_HUMAN DESCRIPTION: RecName: Full=Hyaluronan and proteoglycan link protein 1; AltName: Full=Cartilage-linking protein 1; Short=Cartilage-link protein; AltName: Full=Proteoglycan link protein; Flags: Precursor; FUNCTION: Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. TISSUE SPECIFICITY: Widely expressed. Weakly expressed in the brain. SIMILARITY: Belongs to the HAPLN family. SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain. SIMILARITY: Contains 2 Link domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P10915
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001501 skeletal system development GO:0007155 cell adhesion GO:0007417 central nervous system development GO:0030198 extracellular matrix organization
Cellular Component: GO:0005576 extracellular region GO:0031012 extracellular matrix
Descriptions from all associated GenBank mRNAs
LP896369 - Sequence 1233 from Patent EP3253886. U43328 - Human link protein mRNA, complete cds. BC057808 - Homo sapiens hyaluronan and proteoglycan link protein 1, mRNA (cDNA clone MGC:71729 IMAGE:30341037), complete cds. M63579 - Human cartilage link protein (CRTL1) mRNA, 3' UT region. X17405 - Human mRNA for cartilage link protein. X78076 - H.sapiens CRTL1 gene exons 1, 2, 3, 4 and 5. JD258579 - Sequence 239603 from Patent EP1572962. AK313713 - Homo sapiens cDNA, FLJ94306, Homo sapiens cartilage linking protein 1 (CRTL1), mRNA. HQ448513 - Synthetic construct Homo sapiens clone IMAGE:100071947; CCSB010863_01 hyaluronan and proteoglycan link protein 1 (HAPLN1) gene, encodes complete protein. AB529151 - Synthetic construct DNA, clone: pF1KB5236, Homo sapiens HAPLN1 gene for hyaluronan and proteoglycan link protein 1, without stop codon, in Flexi system. CU691246 - Synthetic construct Homo sapiens gateway clone IMAGE:100021077 5' read HAPLN1 mRNA. X78075 - H.sapiens CRTL1 gene exon 1. JD266298 - Sequence 247322 from Patent EP1572962. JD380401 - Sequence 361425 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P10915 (Reactome details) participates in the following event(s):
US Server
