Human Gene SKP1 (ENST00000353411.11) from GENCODE V44
  Description: Homo sapiens S-phase kinase associated protein 1 (SKP1), transcript variant 2, mRNA. (from RefSeq NM_170679)
RefSeq Summary (NM_170679): This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000353411.11
Gencode Gene: ENSG00000113558.19
Transcript (Including UTRs)
   Position: hg38 chr5:134,148,935-134,176,950 Size: 28,016 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg38 chr5:134,157,733-134,174,022 Size: 16,290 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:134,148,935-134,176,950)mRNA (may differ from genome)Protein (163 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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GeneCardsHGNCHPRDLynxMalacardsMGI
neXtProtOMIMPubMedReactomeUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SKP1_HUMAN
DESCRIPTION: RecName: Full=S-phase kinase-associated protein 1; AltName: Full=Cyclin-A/CDK2-associated protein p19; AltName: Full=Organ of Corti protein 2; Short=OCP-2; AltName: Full=Organ of Corti protein II; Short=OCP-II; AltName: Full=RNA polymerase II elongation factor-like protein; AltName: Full=SIII; AltName: Full=Transcription elongation factor B; AltName: Full=p19A; AltName: Full=p19skp1;
FUNCTION: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110.
PATHWAY: Protein modification; protein ubiquitination.
SUBUNIT: Component of an E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Component of the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC. Part of a SCF(BTRC)-like complex lacking CUL1, which is associated with phosphorylated NFKBIA and RELA; RELA interacts directly with NFKBIA. Component of the SCF(FBXO44) complex, composed of SKP1, CUL1 and FBXO44. Identified in a complex with SKP2, CKS1B and CDKN1B. Interacts with the cyclin A/CDK2 complex. Part of a SCF- like complex consisting of CUL7, RBX1, SKP1 and FBXW8. Part of several SCF complexes containing SKP1 and one of the F-box proteins. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Interacts with FBXO2, FBXO4, FBXW7 and TRIM21. Interacts with FBXO45 (By similarity). Component of the SCF(FBXO17) complex, composed of SKP1, CUL1 and FBXO17. Component of the SCF(FBXO27) complex, composed of SKP1, CUL1 and FBXO27. Component of the SCF(Cyclin F) complex consisting of CUL1, RBX1, SKP1 and CCNF.
INTERACTION: Q9Y297:BTRC; NbExp=4; IntAct=EBI-307486, EBI-307461; P41002:CCNF; NbExp=6; IntAct=EBI-307486, EBI-1207574; Q13616:CUL1; NbExp=6; IntAct=EBI-307486, EBI-359390; Q96CD0:FBXL8; NbExp=3; IntAct=EBI-307486, EBI-2321097; Q86XK2:FBXO11; NbExp=2; IntAct=EBI-307486, EBI-1047804; Q6PJ61:FBXO46; NbExp=3; IntAct=EBI-307486, EBI-2322982; Q9Y3I1:FBXO7; NbExp=2; IntAct=EBI-307486, EBI-1161222; Q9UKB1:FBXW11; NbExp=4; IntAct=EBI-307486, EBI-355189; Q9UKT8:FBXW2; NbExp=2; IntAct=EBI-307486, EBI-914727; Q969U6:FBXW5; NbExp=3; IntAct=EBI-307486, EBI-741068; Q5XUX1:FBXW9; NbExp=3; IntAct=EBI-307486, EBI-2322729; P62136:PPP1CA; NbExp=3; IntAct=EBI-307486, EBI-357253; Q13309:SKP2; NbExp=6; IntAct=EBI-307486, EBI-456291;
SIMILARITY: Belongs to the SKP1 family.

-  Primer design for this transcript
 

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-  MalaCards Disease Associations
  MalaCards Gene Search: SKP1
Diseases sorted by gene-association score: parkinson disease 15, autosomal recessive (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 58.23 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 2078.29 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.3096-0.159 Picture PostScript Text
3' UTR -2755.508798-0.313 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011333 - BTB/POZ_fold
IPR016897 - E3_ubiquit_lig_SCF_Skp
IPR001232 - Skp1_comp
IPR016072 - Skp1_comp_dimer
IPR016073 - Skp1_comp_POZ

Pfam Domains:
PF01466 - Skp1 family, dimerisation domain
PF03931 - Skp1 family, tetramerisation domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1FQV - X-ray MuPIT 1FS1 - X-ray MuPIT 1FS2 - X-ray MuPIT 1LDK - X-ray MuPIT 1P22 - X-ray MuPIT 2ASS - X-ray MuPIT 2AST - X-ray MuPIT 2E31 - X-ray MuPIT 2E32 - X-ray MuPIT 2OVP - X-ray 2OVQ - X-ray 2OVR - X-ray 3L2O - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P63208
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0019904 protein domain specific binding
GO:0097602 cullin family protein binding
GO:0061630 ubiquitin protein ligase activity

Biological Process:
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000209 protein polyubiquitination
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006879 cellular iron ion homeostasis
GO:0010265 SCF complex assembly
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0016055 Wnt signaling pathway
GO:0016567 protein ubiquitination
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0035518 histone H2A monoubiquitination
GO:0038061 NIK/NF-kappaB signaling
GO:0043687 post-translational protein modification
GO:0051403 stress-activated MAPK cascade
GO:0051457 maintenance of protein location in nucleus
GO:0070498 interleukin-1-mediated signaling pathway

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0019005 SCF ubiquitin ligase complex
GO:0031467 Cul7-RING ubiquitin ligase complex
GO:0031519 PcG protein complex


-  Descriptions from all associated GenBank mRNAs
  JD149297 - Sequence 130321 from Patent EP1572962.
JD366279 - Sequence 347303 from Patent EP1572962.
JD105770 - Sequence 86794 from Patent EP1572962.
JD116840 - Sequence 97864 from Patent EP1572962.
JD517382 - Sequence 498406 from Patent EP1572962.
JD105769 - Sequence 86793 from Patent EP1572962.
JD149295 - Sequence 130319 from Patent EP1572962.
JD079448 - Sequence 60472 from Patent EP1572962.
JD243138 - Sequence 224162 from Patent EP1572962.
JD136084 - Sequence 117108 from Patent EP1572962.
JD136083 - Sequence 117107 from Patent EP1572962.
JD312245 - Sequence 293269 from Patent EP1572962.
JD379771 - Sequence 360795 from Patent EP1572962.
Z47087 - H.sapiens mRNA for RNA polymerase II elongation factor-like protein.
JD231623 - Sequence 212647 from Patent EP1572962.
BC065730 - Homo sapiens S-phase kinase-associated protein 1, mRNA (cDNA clone MGC:72058 IMAGE:6672613), complete cds.
JD494191 - Sequence 475215 from Patent EP1572962.
JD170777 - Sequence 151801 from Patent EP1572962.
BC025673 - Homo sapiens S-phase kinase-associated protein 1, mRNA (cDNA clone MGC:34403 IMAGE:5203008), complete cds.
BC009839 - Homo sapiens S-phase kinase-associated protein 1, mRNA (cDNA clone MGC:15226 IMAGE:4053593), complete cds.
AK057110 - Homo sapiens cDNA FLJ32548 fis, clone SPLEN1000013.
U37558 - Human RNA polymerase II elongation factor-like protein OCP2 mRNA, partial cds.
BC020798 - Homo sapiens S-phase kinase-associated protein 1, mRNA (cDNA clone MGC:23780 IMAGE:4243711), complete cds.
JD092184 - Sequence 73208 from Patent EP1572962.
U33760 - Human cyclin A/CDK2-associated p19 (Skp1) mRNA, complete cds.
JD347344 - Sequence 328368 from Patent EP1572962.
KJ892143 - Synthetic construct Homo sapiens clone ccsbBroadEn_01537 SKP1 gene, encodes complete protein.
EU447011 - Synthetic construct Homo sapiens clone IMAGE:100069909; IMAGE:100012220; FLH257129.01L transcription elongation factor B (SIII), polypeptide 1 pseudogene (TCEB1P) gene, encodes complete protein.
EU831628 - Synthetic construct Homo sapiens clone HAIB:100066657; DKFZo007E0119 S-phase kinase-associated protein 1 protein (SKP1) gene, encodes complete protein.
AB385543 - Synthetic construct DNA, clone: pF1KB5194, Homo sapiens SKP1A gene for S-phase kinase-associated protein 1A, complete cds, without stop codon, in Flexi system.
EU831713 - Synthetic construct Homo sapiens clone HAIB:100066742; DKFZo003E0120 S-phase kinase-associated protein 1 protein (SKP1) gene, encodes complete protein.
DQ891512 - Synthetic construct clone IMAGE:100004142; FLH177616.01X; RZPDo839C02126D S-phase kinase-associated protein 1A (p19A) (SKP1A) gene, encodes complete protein.
KJ897558 - Synthetic construct Homo sapiens clone ccsbBroadEn_06952 SKP1 gene, encodes complete protein.
DQ894703 - Synthetic construct Homo sapiens clone IMAGE:100009163; FLH177612.01L; RZPDo839C02125D S-phase kinase-associated protein 1A (p19A) (SKP1A) gene, encodes complete protein.
DQ185037 - Homo sapiens S-phase kinase-associated protein 1A-like mRNA, partial sequence.
JD020929 - Sequence 1953 from Patent EP1572962.
JD028239 - Sequence 9263 from Patent EP1572962.
JD151313 - Sequence 132337 from Patent EP1572962.
JD417281 - Sequence 398305 from Patent EP1572962.
JD289385 - Sequence 270409 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04110 - Cell cycle
hsa04114 - Oocyte meiosis
hsa04120 - Ubiquitin mediated proteolysis
hsa04310 - Wnt signaling pathway
hsa04350 - TGF-beta signaling pathway

BioCyc Knowledge Library
PWY-7511 - protein ubiquitination

BioCarta from NCI Cancer Genome Anatomy Project
h_fbw7Pathway - Cyclin E Destruction Pathway
h_p27Pathway - Regulation of p27 Phosphorylation during Cell Cycle Progression
h_eradPathway - ER¿associated degradation (ERAD) Pathway
h_skp2e2fPathway - E2F1 Destruction Pathway

Reactome (by CSHL, EBI, and GO)

Protein P63208 (Reactome details) participates in the following event(s):

R-HSA-180599 The Vpu:CD4:beta-TrCP complex recruits SKP1
R-HSA-5691167 CUL1, SKP1, FBXL5 bind
R-HSA-8854052 Formation of the SCF-FBXL7 complex
R-HSA-174209 Phosphorylated Emi1 binds the beta-TrCP in the SCF complex
R-HSA-180597 Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex
R-HSA-209125 SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex
R-HSA-1370500 PRLR binds SCF beta-TrCP complex
R-HSA-2130279 Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex
R-HSA-5607723 SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB
R-HSA-5691176 NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5)
R-HSA-8853496 SCF:FBXL7 binds AURKA
R-HSA-187545 Association of Cks1 with SCF(Skp2) complex
R-HSA-1912385 Phosphorylated NICD1 binds FBXW7
R-NUL-2064853 FBXW7 binds phosphorylated NICD1
R-HSA-1852623 Ubiquitination of NICD1 by FBWX7
R-NUL-2064883 FBXW7 mediates ubiquitination of phosphorylated NICD1
R-HSA-9008478 FBXW7 binds RUNX2 and GSK3B
R-HSA-8939688 SCF(SKP2) complex binds RUNX2
R-HSA-8939706 SCF(SKP2) polyubiquitinates RUNX2
R-HSA-174159 Ubiquitination of Emi1 by SCF-beta-TrCP
R-HSA-1168642 SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB
R-HSA-3000339 Phosphorylated BORA binds SCF-beta-TrCp1/2
R-HSA-5684248 SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2
R-HSA-3000335 SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA
R-HSA-5684250 SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2
R-HSA-209063 Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex
R-HSA-2130286 Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)
R-HSA-5610742 SCF(beta-TrCP) ubiquitinates p-GLI1
R-HSA-5610745 SCF(beta-TrCP) ubiquitinates p-GLI2
R-HSA-5610746 SCF(beta-TrCP) ubiquitinates p-GLI3
R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex
R-HSA-983147 Release of E3 from polyubiquitinated substrate
R-HSA-8952620 NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex
R-HSA-8956200 MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex
R-HSA-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases
R-HSA-8854041 SCF-FBXL7 ubiquitinates AURKA
R-HSA-8854051 SCF-FBXL18 ubiquitinates FBXL7
R-HSA-8952618 AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex
R-HSA-187552 Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex
R-HSA-1363328 Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex
R-HSA-1363331 Ubiquitination of p130 (RBL2) by SCF (Skp2)
R-HSA-9008479 FBXW7 polyubiquitinates RUNX2
R-HSA-68946 Phosphorylated Orc1 is ubiquitinated while still associated with chromatin
R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2
R-HSA-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
R-HSA-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
R-HSA-5691108 SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2
R-HSA-187575 Ubiquitination of phospho-p27/p21
R-HSA-180534 Vpu mediated degradation of CD4
R-HSA-917937 Iron uptake and transport
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1
R-HSA-9020702 Interleukin-1 signaling
R-HSA-1170546 Prolactin receptor signaling
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5676590 NIK-->noncanonical NF-kB signaling
R-HSA-202424 Downstream TCR signaling
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-162909 Host Interactions of HIV factors
R-HSA-382551 Transport of small molecules
R-HSA-69275 G2/M Transition
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase
R-HSA-400253 Circadian Clock
R-HSA-446652 Interleukin-1 family signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-195721 Signaling by WNT
R-HSA-5610780 Degradation of GLI1 by the proteasome
R-HSA-5610783 Degradation of GLI2 by the proteasome
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-8951664 Neddylation
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-202403 TCR signaling
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-162906 HIV Infection
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-69231 Cyclin D associated events in G1
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry
R-HSA-1980143 Signaling by NOTCH1
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2644605 FBXW7 Mutants and NOTCH1 in Cancer
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-68949 Orc1 removal from chromatin
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
R-HSA-450294 MAP kinase activation
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins
R-HSA-449147 Signaling by Interleukins
R-HSA-168256 Immune System
R-HSA-162582 Signal Transduction
R-HSA-5610787 Hedgehog 'off' state
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-597592 Post-translational protein modification
R-HSA-1280218 Adaptive Immune System
R-HSA-168249 Innate Immune System
R-HSA-5663205 Infectious disease
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-69236 G1 Phase
R-HSA-69206 G1/S Transition
R-HSA-69242 S Phase
R-HSA-157118 Signaling by NOTCH
R-HSA-2644603 Signaling by NOTCH1 in Cancer
R-HSA-212436 Generic Transcription Pathway
R-HSA-69052 Switching of origins to a post-replicative state
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-448424 Interleukin-17 signaling
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975871 MyD88 cascade initiated on plasma membrane
R-HSA-453276 Regulation of mitotic cell cycle
R-HSA-5358351 Signaling by Hedgehog
R-HSA-392499 Metabolism of proteins
R-HSA-1643685 Disease
R-HSA-1640170 Cell Cycle
R-HSA-453279 Mitotic G1-G1/S phases
R-HSA-5663202 Diseases of signal transduction
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-69239 Synthesis of DNA
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168898 Toll-Like Receptors Cascades
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-74160 Gene expression (Transcription)
R-HSA-69306 DNA Replication
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade

-  Other Names for This Gene
  Alternate Gene Symbols: D3DQ97, D3DQ98, EMC19, ENST00000353411.1, ENST00000353411.10, ENST00000353411.2, ENST00000353411.3, ENST00000353411.4, ENST00000353411.5, ENST00000353411.6, ENST00000353411.7, ENST00000353411.8, ENST00000353411.9, NM_170679, OCP2, P34991, P63208, Q8TAY2, SKP1A, SKP1_HUMAN, TCEB1L, uc003kzc.1, uc003kzc.2, uc003kzc.3, uc003kzc.4, uc003kzc.5, uc003kzc.6
UCSC ID: ENST00000353411.11
RefSeq Accession: NM_170679
Protein: P63208 (aka SKP1_HUMAN)
CCDS: CCDS4171.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.