Human Gene EGR1 (ENST00000239938.5) from GENCODE V44
Description: Homo sapiens early growth response 1 (EGR1), mRNA. (from RefSeq NM_001964) RefSeq Summary (NM_001964): The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]. Gencode Transcript: ENST00000239938.5 Gencode Gene: ENSG00000120738.8 Transcript (Including UTRs) Position: hg38 chr5:138,465,479-138,469,303 Size: 3,825 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr5:138,465,762-138,468,081 Size: 2,320 Coding Exon Count: 2
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF11914 - Domain of unknown function (DUF3432) PF11928 - Domain of unknown function (DUF3446) PF00096 - Zinc finger, C2H2 type
ModBase Predicted Comparative 3D Structure on Q546S1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding GO:0046872 metal ion binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001666 response to hypoxia GO:0002931 response to ischemia GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0009749 response to glucose GO:0030217 T cell differentiation GO:0030509 BMP signaling pathway GO:0032868 response to insulin GO:0035914 skeletal muscle cell differentiation GO:0042981 regulation of apoptotic process GO:0044849 estrous cycle GO:0045080 positive regulation of chemokine biosynthetic process GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046886 positive regulation of hormone biosynthetic process GO:0050725 positive regulation of interleukin-1 beta biosynthetic process GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0071310 cellular response to organic substance GO:0071480 cellular response to gamma radiation GO:0090090 negative regulation of canonical Wnt signaling pathway GO:1901216 positive regulation of neuron death GO:1902949 positive regulation of tau-protein kinase activity GO:2000182 regulation of progesterone biosynthetic process
US Server
