Human Gene FGF1 (ENST00000621536.4) from GENCODE V44
Description: Homo sapiens fibroblast growth factor 1 (FGF1), transcript variant 22, mRNA. (from RefSeq NM_001354958) RefSeq Summary (NM_001257205): The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]. Gencode Transcript: ENST00000621536.4 Gencode Gene: ENSG00000113578.18 Transcript (Including UTRs) Position: hg38 chr5:142,592,179-142,698,070 Size: 105,892 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr5:142,595,290-142,614,127 Size: 18,838 Coding Exon Count: 3
ID:FGF1_HUMAN DESCRIPTION: RecName: Full=Fibroblast growth factor 1; Short=FGF-1; AltName: Full=Acidic fibroblast growth factor; Short=aFGF; AltName: Full=Endothelial cell growth factor; Short=ECGF; AltName: Full=Heparin-binding growth factor 1; Short=HBGF-1; Flags: Precursor; FUNCTION: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. SUBUNIT: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1 (By similarity). Interacts with S100A13. INTERACTION: P21802:FGFR2; NbExp=2; IntAct=EBI-698068, EBI-1028658; P22607:FGFR3; NbExp=3; IntAct=EBI-698068, EBI-348399; SUBCELLULAR LOCATION: Secreted. Cytoplasm. Cytoplasm, cell cortex. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non- classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). SIMILARITY: Belongs to the heparin-binding growth factors family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/fgf1/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P05230
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
