Human Gene HSPA1A (ENST00000375651.7) from GENCODE V44
Description: Homo sapiens heat shock protein family A (Hsp70) member 1A (HSPA1A), mRNA. (from RefSeq NM_005345) RefSeq Summary (NM_005345): This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000375651.7 Gencode Gene: ENSG00000204389.10 Transcript (Including UTRs) Position: hg38 chr6:31,815,543-31,817,942 Size: 2,400 Total Exon Count: 1 Strand: + Coding Region Position: hg38 chr6:31,815,757-31,817,682 Size: 1,926 Coding Exon Count: 1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
FJ224292 - Homo sapiens epididymis secretory protein Li 103 (HEL-S-103) mRNA, complete cds. AX036039 - Sequence 2 from Patent WO0053785. BD273754 - Expression. DQ409329 - Homo sapiens heat shock protein (HSP70) mRNA, 5' UTR. AK295398 - Homo sapiens cDNA FLJ54328 complete cds, highly similar to Heat shock 70 kDa protein 1. AK298078 - Homo sapiens cDNA FLJ53071 complete cds, highly similar to Heat shock 70 kDa protein 1. AK304652 - Homo sapiens cDNA FLJ54408 complete cds, highly similar to Heat shock 70 kDa protein 1. AK304618 - Homo sapiens cDNA FLJ54407 complete cds, highly similar to Heat shock 70 kDa protein 1. AK303980 - Homo sapiens cDNA FLJ54342 complete cds, highly similar to Heat shock 70 kDa protein 1. AK225692 - Homo sapiens mRNA for Heat shock 70 kDa protein 1 variant, clone: SYN07517. AK096017 - Homo sapiens cDNA FLJ38698 fis, clone KIDNE2002015, highly similar to HEAT SHOCK 70 KDA PROTEIN 1. AK291295 - Homo sapiens cDNA FLJ75127 complete cds, highly similar to Homo sapiens heat shock 70kDa protein 1A, mRNA. AK294182 - Homo sapiens cDNA FLJ54303 complete cds, highly similar to Heat shock 70 kDa protein 1. AK298098 - Homo sapiens cDNA FLJ53752 complete cds, highly similar to Heat shock 70 kDa protein 1. AK301574 - Homo sapiens cDNA FLJ54392 complete cds, highly similar to Heat shock 70 kDa protein 1. AK225699 - Homo sapiens mRNA for Heat shock 70 kDa protein 1 variant, clone: SYN09532. AK298056 - Homo sapiens cDNA FLJ54370 complete cds, highly similar to Heat shock 70 kDa protein 1. AK301243 - Homo sapiens cDNA FLJ54389 complete cds, highly similar to Heat shock 70 kDa protein 1. AB209818 - Homo sapiens mRNA for heat shock 70kDa protein 1A variant protein. BC063507 - Homo sapiens heat shock 70kDa protein 1B, mRNA (cDNA clone MGC:74463 IMAGE:4153196), complete cds. BC002453 - Homo sapiens heat shock 70kDa protein 1A, mRNA (cDNA clone MGC:1309 IMAGE:3345864), complete cds. GQ891470 - Homo sapiens clone HEL-S-191 epididymis secretory sperm binding protein mRNA, complete cds. DQ596815 - Homo sapiens piRNA piR-34881, complete sequence. JD180856 - Sequence 161880 from Patent EP1572962. JD538175 - Sequence 519199 from Patent EP1572962. JD248250 - Sequence 229274 from Patent EP1572962. JD103981 - Sequence 85005 from Patent EP1572962. CU679297 - Synthetic construct Homo sapiens gateway clone IMAGE:100017440 5' read HSPA1A mRNA. KJ897012 - Synthetic construct Homo sapiens clone ccsbBroadEn_06406 HSPA1A gene, encodes complete protein. AB527245 - Synthetic construct DNA, clone: pF1KB9773, Homo sapiens HSPA1A gene for heat shock 70kDa protein 1A, without stop codon, in Flexi system. DQ896426 - Synthetic construct Homo sapiens clone IMAGE:100010886; FLH194198.01L; RZPDo839G0769D heat shock 70kDa protein 1A (HSPA1A) gene, encodes complete protein. EU176434 - Synthetic construct Homo sapiens clone IMAGE:100006510; FLH194202.01X; RZPDo839G0779D heat shock 70kDa protein 1A (HSPA1A) gene, encodes complete protein. JD024959 - Sequence 5983 from Patent EP1572962. JD034422 - Sequence 15446 from Patent EP1572962. L19690 - Human MHC class I mRNA sequence. JD552181 - Sequence 533205 from Patent EP1572962. JD551319 - Sequence 532343 from Patent EP1572962. JD444720 - Sequence 425744 from Patent EP1572962. JD236193 - Sequence 217217 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03040 - Spliceosome hsa04010 - MAPK signaling pathway hsa04144 - Endocytosis hsa04612 - Antigen processing and presentation hsa05020 - Prion diseases
BioCarta from NCI Cancer Genome Anatomy Project h_p53hypoxiaPathway - Hypoxia and p53 in the Cardiovascular system h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) h_tidPathway - Chaperones modulate interferon Signaling Pathway
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