Human Gene PHF1 (ENST00000374516.8) from GENCODE V44
Description: Homo sapiens PHD finger protein 1 (PHF1), transcript variant 3, non-coding RNA. (from RefSeq NR_027692) RefSeq Summary (NM_024165): This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]. Gencode Transcript: ENST00000374516.8 Gencode Gene: ENSG00000112511.18 Transcript (Including UTRs) Position: hg38 chr6:33,411,014-33,416,439 Size: 5,426 Total Exon Count: 15 Strand: + Coding Region Position: hg38 chr6:33,412,264-33,416,098 Size: 3,835 Coding Exon Count: 14
ID:PHF1_HUMAN DESCRIPTION: RecName: Full=PHD finger protein 1; Short=Protein PHF1; AltName: Full=Polycomb-like protein 1; Short=hPCl1; FUNCTION: Transcriptional repressor. May promote methylation of histone H3 on 'Lys-27' by the PRC2/EED-EZH2 complex. SUBUNIT: Interacts with CHMP1 (By similarity). Interacts with the PRC2 complex. SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, centrosome. Note=Localizes specifically to the promoters of numerous target genes. Co-localizes with NEK6 in the centrosome. TISSUE SPECIFICITY: Highest levels in heart, skeletal muscle, and pancreas, lower levels in brain, placenta, lung, liver and kidney. SIMILARITY: Contains 2 PHD-type zinc fingers.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43189
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
