Human Gene ZNF76 (ENST00000373953.8) from GENCODE V44
  Description: Homo sapiens zinc finger protein 76 (ZNF76), transcript variant 1, mRNA. (from RefSeq NM_003427)
Gencode Transcript: ENST00000373953.8
Gencode Gene: ENSG00000065029.15
Transcript (Including UTRs)
   Position: hg38 chr6:35,259,735-35,295,985 Size: 36,251 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg38 chr6:35,281,152-35,295,248 Size: 14,097 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:35,259,735-35,295,985)mRNA (may differ from genome)Protein (570 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZNF76_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 76; AltName: Full=Zinc finger protein 523;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
TISSUE SPECIFICITY: Testis.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 7 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ZNF76
Diseases sorted by gene-association score: cataract 1, multiple types (3)

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 27.55 RPKM in Pituitary
Total median expression: 509.92 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -83.80203-0.413 Picture PostScript Text
3' UTR -276.00737-0.374 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type

ModBase Predicted Comparative 3D Structure on P36508
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006359 regulation of transcription from RNA polymerase III promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0045944 positive regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK304626 - Homo sapiens cDNA FLJ55178 complete cds, highly similar to Zinc finger protein 76.
AB208784 - Homo sapiens mRNA for zinc finger protein 76 (expressed in testis) variant protein.
AK302903 - Homo sapiens cDNA FLJ56528 complete cds, highly similar to Zinc finger protein 76.
AK295276 - Homo sapiens cDNA FLJ56983 complete cds, highly similar to Zinc finger protein 76.
AK310877 - Homo sapiens cDNA, FLJ17919.
AK294605 - Homo sapiens cDNA FLJ60108 complete cds, highly similar to Zinc finger protein 76.
BC002549 - Homo sapiens zinc finger protein 76 (expressed in testis), mRNA (cDNA clone MGC:1577 IMAGE:3139040), complete cds.
BC000133 - Homo sapiens zinc finger protein 76 (expressed in testis), mRNA (cDNA clone MGC:5059 IMAGE:2900036), complete cds.
M91592 - Human zinc-finger protein (ZNF76) gene, partial cds.
JD386833 - Sequence 367857 from Patent EP1572962.
JD353279 - Sequence 334303 from Patent EP1572962.
JD419095 - Sequence 400119 from Patent EP1572962.
JD334147 - Sequence 315171 from Patent EP1572962.
KJ892412 - Synthetic construct Homo sapiens clone ccsbBroadEn_01806 ZNF76 gene, encodes complete protein.
AB464413 - Synthetic construct DNA, clone: pF1KB7873, Homo sapiens ZNF76 gene for zinc finger protein 76, without stop codon, in Flexi system.
BT007316 - Homo sapiens zinc finger protein 76 (expressed in testis) mRNA, complete cds.
JD487355 - Sequence 468379 from Patent EP1572962.
JD465879 - Sequence 446903 from Patent EP1572962.
JD121057 - Sequence 102081 from Patent EP1572962.
JD228825 - Sequence 209849 from Patent EP1572962.
JD392907 - Sequence 373931 from Patent EP1572962.
JD454572 - Sequence 435596 from Patent EP1572962.
JD042502 - Sequence 23526 from Patent EP1572962.
JD215398 - Sequence 196422 from Patent EP1572962.
JD384898 - Sequence 365922 from Patent EP1572962.
JD399614 - Sequence 380638 from Patent EP1572962.
JD126990 - Sequence 108014 from Patent EP1572962.
JD420933 - Sequence 401957 from Patent EP1572962.
JD537169 - Sequence 518193 from Patent EP1572962.
JD358047 - Sequence 339071 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: D6S229E, ENST00000373953.1, ENST00000373953.2, ENST00000373953.3, ENST00000373953.4, ENST00000373953.5, ENST00000373953.6, ENST00000373953.7, NM_003427, P36508, Q9BQB2, uc003oki.1, uc003oki.2, uc003oki.3, ZNF523, ZNF76_HUMAN
UCSC ID: ENST00000373953.8
RefSeq Accession: NM_003427
Protein: P36508 (aka ZNF76_HUMAN or ZN76_HUMAN)
CCDS: CCDS4801.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.