Human Gene MTCH1 (ENST00000373616.9) from GENCODE V44
Description: Homo sapiens mitochondrial carrier 1 (MTCH1), transcript variant 1, mRNA; nuclear gene for mitochondrial product. (from RefSeq NM_014341) RefSeq Summary (NM_014341): This gene encodes a member of the mitochondrial carrier family. The encoded protein is localized to the mitochondrion inner membrane and induces apoptosis independent of the proapoptotic proteins Bax and Bak. Pseudogenes on chromosomes 6 and 11 have been identified for this gene. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Oct 2012]. Gencode Transcript: ENST00000373616.9 Gencode Gene: ENSG00000137409.21 Transcript (Including UTRs) Position: hg38 chr6:36,968,141-36,986,298 Size: 18,158 Total Exon Count: 12 Strand: - Coding Region Position: hg38 chr6:36,968,903-36,986,173 Size: 17,271 Coding Exon Count: 12
ID:MTCH1_HUMAN DESCRIPTION: RecName: Full=Mitochondrial carrier homolog 1; AltName: Full=Presenilin-associated protein; FUNCTION: Potential mitochondrial transporter. May play a role in apoptosis. SUBUNIT: Interacts with PSEN1. SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (Potential). TISSUE SPECIFICITY: Widely expressed with a predominant expression in brain. SIMILARITY: Belongs to the mitochondrial carrier family. SIMILARITY: Contains 2 Solcar repeats. SEQUENCE CAUTION: Sequence=AAF07936.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00153 - Mitochondrial carrier protein
ModBase Predicted Comparative 3D Structure on Q9NZJ7
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006915 apoptotic process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0009966 regulation of signal transduction GO:0043065 positive regulation of apoptotic process GO:0045161 neuronal ion channel clustering
US Server
