Human Gene MRPL14 (ENST00000372014.5) from GENCODE V44
Description: Homo sapiens mitochondrial ribosomal protein L14 (MRPL14), transcript variant 1, mRNA; nuclear gene for mitochondrial product. (from RefSeq NM_032111) RefSeq Summary (NM_032111): This nuclear gene encodes a protein component of the 39S subunit of the mitochondrial ribosome. A pseudogene of this gene is found on chromosome 17. [provided by RefSeq, Jan 2016]. Gencode Transcript: ENST00000372014.5 Gencode Gene: ENSG00000180992.7 Transcript (Including UTRs) Position: hg38 chr6:44,113,451-44,127,452 Size: 14,002 Total Exon Count: 3 Strand: - Coding Region Position: hg38 chr6:44,113,843-44,116,611 Size: 2,769 Coding Exon Count: 2
ID:RM14_HUMAN DESCRIPTION: RecName: Full=39S ribosomal protein L14, mitochondrial; Short=L14mt; Short=MRP-L14; AltName: Full=39S ribosomal protein L32, mitochondrial; Short=L32mt; Short=MRP-L32; Flags: Precursor; FUNCTION: Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable). SUBUNIT: Part of the mitochondrial ribosome large subunit (39S) (By similarity); associates with MALSU1. SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: Belongs to the ribosomal protein L14P family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00238 - Ribosomal protein L14p/L23e
ModBase Predicted Comparative 3D Structure on Q6P1L8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC010416 - Homo sapiens mitochondrial ribosomal protein L14, mRNA (cDNA clone IMAGE:4025493), with apparent retained intron. BC065005 - Homo sapiens mitochondrial ribosomal protein L14, mRNA (cDNA clone MGC:70566 IMAGE:6052682), complete cds. JD368071 - Sequence 349095 from Patent EP1572962. JD111813 - Sequence 92837 from Patent EP1572962. JD558862 - Sequence 539886 from Patent EP1572962. AK312086 - Homo sapiens cDNA, FLJ92367, highly similar to Homo sapiens mitochondrial ribosomal protein L14 (MRPL14), nucleargene encoding mitochondrial protein, mRNA. HQ448655 - Synthetic construct Homo sapiens clone IMAGE:100072094; CCSB012298_01 mitochondrial ribosomal protein L14 (MRPL14) gene, encodes complete protein. KJ894591 - Synthetic construct Homo sapiens clone ccsbBroadEn_03985 MRPL14 gene, encodes complete protein. AB529105 - Synthetic construct DNA, clone: pF1KB4553, Homo sapiens MRPL14 gene for mitochondrial ribosomal protein L14, without stop codon, in Flexi system. CU687994 - Synthetic construct Homo sapiens gateway clone IMAGE:100021548 5' read MRPL14 mRNA. LF210855 - JP 2014500723-A/18358: Polycomb-Associated Non-Coding RNAs. MA446432 - JP 2018138019-A/18358: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q6P1L8 (Reactome details) participates in the following event(s):
R-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNA R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits R-HSA-5389848 TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA R-HSA-5389857 Peptide transfer from P-site to A-site (peptide bond formation) R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome R-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP R-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNA R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA R-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA R-HSA-5368286 Mitochondrial translation initiation R-HSA-5419276 Mitochondrial translation termination R-HSA-5368287 Mitochondrial translation R-HSA-5389840 Mitochondrial translation elongation R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins
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