Human Gene TCF21 (ENST00000367882.5) from GENCODE V44
Description: Homo sapiens transcription factor 21 (TCF21), transcript variant 2, mRNA. (from RefSeq NM_003206) RefSeq Summary (NM_003206): TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000367882.5 Gencode Gene: ENSG00000118526.7 Transcript (Including UTRs) Position: hg38 chr6:133,889,113-133,892,257 Size: 3,145 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr6:133,889,398-133,891,802 Size: 2,405 Coding Exon Count: 2
ID:TCF21_HUMAN DESCRIPTION: RecName: Full=Transcription factor 21; Short=TCF-21; AltName: Full=Capsulin; AltName: Full=Class A basic helix-loop-helix protein 23; Short=bHLHa23; AltName: Full=Epicardin; AltName: Full=Podocyte-expressed 1; Short=Pod-1; FUNCTION: Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types. SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3 and binds the E box (5'-CANNTG-3'). SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43680
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0042826 histone deacetylase binding GO:0043425 bHLH transcription factor binding GO:0046983 protein dimerization activity GO:0050681 androgen receptor binding GO:0070888 E-box binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001657 ureteric bud development GO:0001658 branching involved in ureteric bud morphogenesis GO:0001763 morphogenesis of a branching structure GO:0001822 kidney development GO:0001944 vasculature development GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007530 sex determination GO:0007548 sex differentiation GO:0009887 animal organ morphogenesis GO:0014707 branchiomeric skeletal muscle development GO:0030855 epithelial cell differentiation GO:0032835 glomerulus development GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048286 lung alveolus development GO:0048536 spleen development GO:0048557 embryonic digestive tract morphogenesis GO:0048608 reproductive structure development GO:0048732 gland development GO:0060008 Sertoli cell differentiation GO:0060021 palate development GO:0060425 lung morphogenesis GO:0060426 lung vasculature development GO:0060435 bronchiole development GO:0060539 diaphragm development GO:0060541 respiratory system development GO:0060766 negative regulation of androgen receptor signaling pathway GO:0072162 metanephric mesenchymal cell differentiation GO:0072277 metanephric glomerular capillary formation
US Server
