Human Gene PKD1L1 (ENST00000289672.7) from GENCODE V43
Description: Homo sapiens polycystin 1 like 1, transient receptor potential channel interacting (PKD1L1), mRNA. (from RefSeq NM_138295) RefSeq Summary (NM_138295): This gene encodes a member of the polycystin protein family containing 11 transmembrane domains, a receptor for egg jelly (REJ) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. The encoded protein may play a role in the male reproductive system. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000289672.7 Gencode Gene: ENSG00000158683.10 Transcript (Including UTRs) Position: hg38 chr7:47,774,614-47,948,466 Size: 173,853 Total Exon Count: 57 Strand: - Coding Region Position: hg38 chr7:47,775,143-47,948,440 Size: 173,298 Coding Exon Count: 57
ID:PK1L1_HUMAN DESCRIPTION: RecName: Full=Polycystic kidney disease protein 1-like 1; AltName: Full=PC1-like 1 protein; AltName: Full=Polycystin-1L1; FUNCTION: May have a role in the heart and in the male reproductive system. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). TISSUE SPECIFICITY: Detected in testis and in fetal and adult heart. SIMILARITY: Belongs to the polycystin family. SIMILARITY: Contains 1 GPS domain. SIMILARITY: Contains 2 PKD domains. SIMILARITY: Contains 1 PLAT domain. SIMILARITY: Contains 1 REJ domain. SEQUENCE CAUTION: Sequence=AAQ89117.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TDX9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.