Human Gene SLC25A40 (ENST00000341119.10) from GENCODE V44
  Description: Homo sapiens solute carrier family 25 member 40 (SLC25A40), mRNA. (from RefSeq NM_018843)
RefSeq Summary (NM_018843): SLC25A40 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Gencode Transcript: ENST00000341119.10
Gencode Gene: ENSG00000075303.13
Transcript (Including UTRs)
   Position: hg38 chr7:87,833,568-87,876,360 Size: 42,793 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg38 chr7:87,836,249-87,858,727 Size: 22,479 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:87,833,568-87,876,360)mRNA (may differ from genome)Protein (338 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMGIneXtProtOMIM
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: S2540_HUMAN
DESCRIPTION: RecName: Full=Solute carrier family 25 member 40; AltName: Full=Mitochondrial carrier family protein;
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the mitochondrial carrier family.
SIMILARITY: Contains 3 Solcar repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.22 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 202.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -110.30358-0.308 Picture PostScript Text
3' UTR -570.582681-0.213 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002067 - Mit_carrier
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

ModBase Predicted Comparative 3D Structure on Q8TBP6
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsemblWormBase 
Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence 
AlignmentAlignmentAlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0022857 transmembrane transporter activity

Biological Process:
GO:0006839 mitochondrial transport
GO:0055085 transmembrane transport

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  DQ596959 - Homo sapiens piRNA piR-35025, complete sequence.
AK290848 - Homo sapiens cDNA FLJ76036 complete cds, highly similar to Homo sapiens mitochondrial carrier family protein (MCFP), mRNA.
BC027322 - Homo sapiens solute carrier family 25, member 40, mRNA (cDNA clone MGC:17030 IMAGE:4345193), complete cds.
AK223020 - Homo sapiens mRNA for mitochondrial carrier family protein variant, clone: HSI11216.
AF125531 - Homo sapiens mitochondrial carrier family protein mRNA, complete cds.
JD172034 - Sequence 153058 from Patent EP1572962.
JD090853 - Sequence 71877 from Patent EP1572962.
HQ447189 - Synthetic construct Homo sapiens clone IMAGE:100070483; CCSB002553_01 solute carrier family 25, member 40 (SLC25A40) gene, encodes complete protein.
KJ894295 - Synthetic construct Homo sapiens clone ccsbBroadEn_03689 SLC25A40 gene, encodes complete protein.
CU693260 - Synthetic construct Homo sapiens gateway clone IMAGE:100018143 5' read SLC25A40 mRNA.
JD394963 - Sequence 375987 from Patent EP1572962.
JD458938 - Sequence 439962 from Patent EP1572962.
JD455227 - Sequence 436251 from Patent EP1572962.
DQ592121 - Homo sapiens piRNA piR-59233, complete sequence.
JD414040 - Sequence 395064 from Patent EP1572962.
JD239793 - Sequence 220817 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K483, D6W5P6, ENST00000341119.1, ENST00000341119.2, ENST00000341119.3, ENST00000341119.4, ENST00000341119.5, ENST00000341119.6, ENST00000341119.7, ENST00000341119.8, ENST00000341119.9, MCFP, NM_018843, Q53GB1, Q8TBP6, Q9UHR1, S2540_HUMAN, uc003uje.1, uc003uje.2, uc003uje.3, uc003uje.4, uc003uje.5
UCSC ID: ENST00000341119.10
RefSeq Accession: NM_018843
Protein: Q8TBP6 (aka S2540_HUMAN)
CCDS: CCDS5610.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.