ID:SHC3_HUMAN DESCRIPTION: RecName: Full=SHC-transforming protein 3; AltName: Full=Neuronal Shc; Short=N-Shc; AltName: Full=Protein Rai; AltName: Full=SHC-transforming protein C; AltName: Full=Src homology 2 domain-containing-transforming protein C3; Short=SH2 domain protein C3; FUNCTION: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons. SUBUNIT: Interacts with the Trk receptors in a phosphotyrosine- dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors. INTERACTION: P05067:APP; NbExp=2; IntAct=EBI-79084, EBI-77613; TISSUE SPECIFICITY: Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord. PTM: Tyrosine phosphorylated. SIMILARITY: Contains 1 PID domain. SIMILARITY: Contains 1 SH2 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92529
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
