Human Gene PTPN3 (ENST00000374541.4) from GENCODE V44
Description: Homo sapiens protein tyrosine phosphatase non-receptor type 3 (PTPN3), transcript variant 1, mRNA. (from RefSeq NM_002829) RefSeq Summary (NM_002829): The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]. Gencode Transcript: ENST00000374541.4 Gencode Gene: ENSG00000070159.14 Transcript (Including UTRs) Position: hg38 chr9:109,375,700-109,498,307 Size: 122,608 Total Exon Count: 26 Strand: - Coding Region Position: hg38 chr9:109,379,556-109,463,434 Size: 83,879 Coding Exon Count: 25
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF09380 - FERM C-terminal PH-like domain PF00373 - FERM central domain PF09379 - FERM N-terminal domain PF00595 - PDZ domain (Also known as DHR or GLGF) PF00102 - Protein-tyrosine phosphatase
ModBase Predicted Comparative 3D Structure on P26045
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.